Results 181 to 190 of about 316,644 (265)

Comparative analysis of genomic prediction approaches for multiple time-resolved traits in maize. [PDF]

Theor Appl Genet
Hobby D, Lindner R, Mbebi AJ, Tong H, Nikoloski Z.   +4 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

DNAwhisper: An Integrated Deep Learning Pyramidal Framework for Multi-Trait Genomic Prediction and Adaptive Marker Prioritisation. [PDF]

Plant Biotechnol J
Ma Y, Li X, Ji X, Wang C, Zhang D, Zhai T, Wang H, Liu P.   +7 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Genomic prediction powered by multi-omics data. [PDF]

Front Genet
Montesinos-López OA, Montesinos-López A, Mosqueda-González BA, Delgado-Enciso I, Chavira-Flores M, Crossa J, Dreisigacker S, Sun J, Ortiz R.   +8 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Ensemble-based genomic prediction for maize flowering time improves prediction accuracy and reveals novel insights into trait genetic variation. [PDF]

G3 (Bethesda)
Tomura S, Powell O, Wilkinson MJ, Cooper M.   +3 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Enhancing genomic prediction for key production traits in chickens through ultrasound phenotyping and multi-model comparative analysis. [PDF]

J Anim Sci Biotechnol
Zhu R, Jiang Y, Xiong W, Zhang Y, Lian Z, Gou D, Li Z, Wang X, Deng X.   +8 more
europepmc   +1 more source