Results 221 to 230 of about 844,050 (314)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Editorial: Insights in livestock genomics. [PDF]

Front Genet
Wu XL, Chen SY, Sölkner J, Cassandro M.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Mapping pathogen genomics training provision: a structured analysis within a global consortium network. [PDF]

Front Public Health
Matimba A, Garson KL, Trovão NS, George S, Li YT, Evans D, Batista da Rocha J, Otieno J, Mokaya J, Calvert-Joshua T, Blankenship HM, Mulder N.   +11 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Imagining Genomics and Population Health in 2050: Anticipating Future Research, Policy, and Governance Needs.

Public Health Genomics
Knoppers BM, Joly Y, Zawati MANH, Alsafar H, Barrett JC, Blackburn L, Chung BH, Cornel MC, Dove ES, Glazer D, Ho CW, Khoury MJ, Lewis ACF, Lucassen A, Mills PFR, Mitchell C, Mulder N, Newson AJ, Ng A, Pharoah PDP, Rahimzadeh V, Roberts MC, Sanderson SC, Skopek JM, Zimmern R, Meslin EM.   +25 more
europepmc   +1 more source

Correction: Comprehensive genomic study of Plasmodium falciparum in Sierra Leone: genetic variation and resistance patterns. [PDF]

BMC Genomics
Zhan XJ, Chen SB, Wang TY, Duan YW, Shen HM, Chen JH, Xie JJ.   +6 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Special Issue "Human Traits and Genomics: An Integrative Perspective". [PDF]

Int J Mol Sci
Saccone S, Larizza L, Malerba G.
europepmc   +1 more source