Results 341 to 350 of about 1,946,862 (417)

Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior

Advanced Biology, EarlyView.
Human pluripotent stem cells (hPSCs) with TP53‐depleting mutations are generated, mimicking commonly occurring events in vitro. Loss of TP53 does not alter pluripotency status or in vitro differentiation potential but causes genetic instability and transcriptome changes and confers superior clonal and anchorage‐free growth and higher chemotherapeutic ...
Joaquin Montilla‐Rojo, Thomas F. Eleveld, Marnix van Soest, Sanne Hillenius, Dennis M. Timmerman, Ad J. M. Gillis, Bernard A. J. Roelen, Christine L. Mummery, Leendert H. J. Looijenga, Daniela C. F. Salvatori   +9 more
wiley   +1 more source

Building a Genomics-Informed Nursing Workforce: Recommendations for Oncology Nursing Practice and Beyond. [PDF]

Curr Oncol
Limoges J, Puddester R, Gretchev A, Chiu P, Calzone K, Leslie K, Pike A, Letourneau N.   +7 more
europepmc   +1 more source

Molecular-Marker-Facilitated Investigations of Quantitative-Trait Loci in Maize. I. Numbers, Genomic Distribution and Types of Gene Action

, 1987
M. D. Edwards, C. W. Stuber, Jonathan F. Wendel   +2 more
openalex   +1 more source

Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds

Advanced Biology, EarlyView.
The relationship between proteome size, amino acid composition, and lifespan across 276 vertebrate species is investigated. Proteome size correlates positively with lifespan in mammals but negatively in birds and fish. While proteome composition varies among classes, no single amino acid frequency correlates with lifespan.
Juliano Morimoto, Zuzanna Pietras
wiley   +1 more source

Boosting GPT models for genomics analysis: generating trusted genetic variant annotations and interpretations through RAG and Fine-tuning. [PDF]

Bioinform Adv
Lu S, Cosgun E.
europepmc   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Ontology‐Based Digital Infrastructure for Data‐Driven Glass Development

Advanced Engineering Materials, EarlyView.
This work addresses the inefficiencies in traditional glass development by implementing an ontology‐based digital infrastructure coupled with a high‐throughput robotic melting system. The approach integrates machine learning models, predictive tools, and a semantic database.
Ya‐Fan Chen, Felix Arendt, Hansjörg Bornhöft, Andréa S. S. de Camargo, Joachim Deubener, Andreas Diegeler, Shravya Gogula, Altair T. Contreras Jaimes, Sebastian Kempf, Martin Kilo, René Limbach, Ralf Müller, Rick Niebergall, Zhiwen Pan, Frank Puppe, Stefan Reinsch, Gerhard Schottner, Simon Stier, Tina Waurischk, Lothar Wondraczek, Marek Sierka   +20 more
wiley   +1 more source

Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol. [PDF]

BMC Nephrol
Mallawaarachchi A, McCarthy H, Forbes TA, Jayasinghe K, Patel C, Alexander SI, Boughtwood T, Braithwaite J, Chakera A, Crafter S, Deveson IW, Faull R, Harris T, Johnstone L, Jose M, Leaver A, Little MH, MacArthur D, Mattiske T, Mincham C, Nicholls K, Quinlan C, Quinn MCJ, Rangan G, Ryan J, Simons C, Smyth I, Sundaram M, Trnka P, Wedd L, Biros E, Stark Z, Mallett A.   +32 more
europepmc   +1 more source

Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting

Advanced Functional Materials, EarlyView.
Integrating selective RNA shortcut, targeted gene isolation, and micro‐arrayed nanoimaging, the NanoPick‐array platform excels in detecting severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) at just 60 copies µL−1 and accurately differentiating variants at the single‐nucleotide level. It ensures 100% accuracy for samples with cycle threshold (
Zixun Wang, Xi Zhao, Wan‐Mui Chan, Xianglin Ji, Linfeng Huang, Xi Xie, Wei Li, Wenjun Zhang, Kelvin Kai‐Wang To, Peng Shi   +9 more
wiley   +1 more source

Genomics Research on the Road of Studying Biology and Virulence of Cereal Rust Fungi. [PDF]

Mol Plant Pathol
Guan H, Zhang P, Park RF, Ding Y.
europepmc   +1 more source