Results 51 to 60 of about 9,641,170 (252)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Plants, 2023 Soybean is a crop in high demand, in particular as a crucial source of plant protein. As a short-day plant, soybean is sensitive to the latitude of the growing site. Consequently, varieties that are well adapted to higher latitudes are required to expand
Cleo A. Döttinger +3 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
GENOTYPE-ENVIRONMENT INTERACTION IN SPRING WHEAT (Triticuin spp.) [PDF]
, 2014 A Thesis Submitted to the Faculty of Agriculture, Sher-e-Bangla Agricultural University, Dhaka, In partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN GENETICS AND PLANT BREEDING SEMESTER: January-June, 2014A field ...
ISLAM, MD. SHFUL
core
AMMI and GGE biplot analyses of genotype-environment interaction in spring barley lines [PDF]
, 2017 Yield stability depends on the resistance of varieties and hybrids to stressful environmental factors. Assessment of genotype-environment interaction helps breeders select the best genotypes for submission to the state variety trials.
P. N. Solonechnyi
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Disentangling non-crossover and crossover genotype by environment interaction for selection [PDF]
Genotype by environment interaction (GEI) is often categorised as non-crossover or crossover interaction,reflecting changes in the scale of genotype response between environments or changes in genotype rank.• The objective of this research is to ...
Tolhurst, Daniel; id_orcid +1 more
core +2 more sources
Environment-dependent genetic correlations between development time and body mass in a scorpionfly [PDF]
, 2007 Engqvist L. Environment-dependent genetic correlations between development time and body mass in a scorpionfly. Zoology. 2007;110(5):344-353.Development time and body mass at maturation are two important fitness traits fundamental for our understanding ...
Engqvist, Leif ; https://orcid.org/
core +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source