Results 91 to 100 of about 107,212 (246)
Developmental context and the genotype‐phenotype map
The FASEB Journal, 2015 Much of what we know about phenotypic variation comes from the study of mutations and disease phenotypes that arise as genetic and environmental influences interact within a developmental program. These studies routinely analyze disease traits as isolated phenomena.
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Advanced Science, EarlyView.We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang +10 more
wiley +1 more source
Deciphering Genotype-Phenotype Connections: Leveraging Pangenomes and Comprehensive Genome Variation
My thesis explores the application of advanced techniques for discovery of genetic variation and pangenomic approaches to enhance our understanding of genetic variation and genotype-phenotype relationships in two key model organisms: the HXB/BXH ...
Villani, Flavia
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Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
Linking microbial communities to ecosystem functions: what we can learn from genotype-phenotype mapping in organisms. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2020 Morris A, Meyer K, Bohannan B.
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Climate Change Threatens Micronutrient Density of European Winter Wheat
Advanced Science, EarlyView.Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao +17 more
wiley +1 more source
Implementing von Neumann’s architecture for machine self reproduction within the tierra artificial life platform to investigate evolvable genotype-phenotype mappings [PDF]
, 2015 John von Neumann first presented his theory of machine self reproduction in the late 1940's in which he described a machine capable of performing the logical steps necessary to accommodate self reproduction, and provided an explanation in principle for ...
Baugh, Declan
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Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Genotype-Phenotype-Mapping and Neutral Variation - A case study in Genetic Programming
, 1994 . We propose the application of a genotype-phenotype mapping to the solution of constrained optimization problems. The method consists of strictly separating the search space of genotypes from the solution space of phenotypes.
R. Manner (eds +3 more
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