Results 161 to 170 of about 957,013 (262)

Progressive Myopenia and Functional Decline in the Winnie Mouse Model of Chronic Colitis. [PDF]

Muscles
Sharma S, Debruin D, Devereaux J, Hayes A, Nurgali K, Duque G.   +5 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Establishment of a Tetra-Primer ARMS-PCR Assay to Discriminate Genotypes I and II African Swine Fever Viruses. [PDF]

Transbound Emerg Dis
Ding L, Xue K, Ren T, Zhang S, Tesfagaber W, Zhang Z, Guan F, Zhang J, Zhu Y, Liu R, Li F, Bu Z, Zhang Q, Sun E, Zhao D.   +14 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Comparative analysis of viral biological characteristics and pathogenicity of representative prevalent avian reovirus strains from genotypes I to V. [PDF]

Virulence
Meng F, Li R, Zhang D, Zhou H, Zhou C, Wang N, Wang Y, Guo F, Ding L, Lang F, Yang L, Cheng Z.   +11 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Biochemical and Nutritional Profiling of Pistachio Genotypes Grafted Onto <i>Pistacia khinjuk</i> Rootstocks. [PDF]

Food Sci Nutr
Aglar E, Ozturk B, Uyak C, Dogan A, Tekin O, Durmaz O, Alan D, Ates U.   +7 more
europepmc   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Relationship of Genetic Variability (<i>HIF-1Α</i> (rs11549465; P582S), <i>TMPRSS6</i> (rs855791; V736A) and <i>ABO</i> (rs651007) and Iron Deficiency in Repeated Blood Donors in 2023: A Cross-Sectional Study Towards Individualized Health Management. [PDF]

Health Sci Rep
Samiee MP, Chegini A, Shahabi M, Teimourpour A.   +3 more
europepmc   +1 more source