Results 231 to 240 of about 9,640,965 (252)

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang   +12 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

open access: yesAdvanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong   +15 more
wiley   +1 more source

Effect of Genotype × Environment Interaction on Yield of Maize Hybrids in Greece Using AMMI Analysis

Agronomy, 2021
George Katsaros   +2 more
exaly  

No Gene-Environment Interactions Found in Million Women Study of Breast Cancer

Ca-A Cancer Journal for Clinicians, 2010
John Henry Dreyfuss
exaly  

Human Papillomavirus Genotype Distributions Inform Screening and Vaccination Policy

Ca-A Cancer Journal for Clinicians, 2009
Mary Desmond Pinkowish, M D Pinkowish
exaly  

Genotype by Environment Interactions Across Diverse Rainfed Lowland Rice Environments

Field Crops Research, 1999
Joel Siopongco, L J Wade, S Sarkarung
exaly  

A Genomic Bias for Genotype–Environment Interactions in C. Elegans

Molecular Systems Biology, 2012
Craig P Hunter   +2 more
exaly  

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