Results 11 to 20 of about 1,007,160 (300)

Genotype-by-genotype epistasis for exploratory behaviour inD. simulans [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2020
Social interactions can influence the expression and underlying genetic basis of many traits. Yet, empirical investigations of indirect genetic effects (IGEs) and genotype-by-genotype epistasis—quantitative genetics parameters representing the role of genetic variation in a focal individual and its interacting partners in producing the observed trait ...
Allison Jaffe, Madeline P. Burns, Julia B. Saltz   +2 more
openaire   +2 more sources

Genotyping of UGT1A1*80 as an Alternative to UGT1A1*28 Genotyping in Spain

Pharmaceutics, 2022
Background: The variant rs34983651 (UGT1A1*28) and its genotyping are used to prevent irinotecan-induced toxicity. Several variants are in close linkage disequilibrium. Our objective was to evaluate the potential correlation of genotyping UGT1A1*80 instead of UGT1A1*28 in different populations.
Adrián Bravo-Gómez, Sara Salvador-Martín, Paula Zapata-Cobo, María Sanjurjo-Sáez, Luis Andrés López-Fernández   +4 more
openaire   +3 more sources

Methodology for clinical genotyping of CYP2D6 and CYP2C19 [PDF]

Translational Psychiatry, 2021
Abstract Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is no consensus regarding validated methodology for clinical
Beatriz Carvalho Henriques, Avery Buchner, Xiuying Hu, Yabing Wang, Vasyl Yavorskyy, Keanna Wallace, Rachael Dong, Kristina Martens, Michael S. Carr, Bahareh Behroozi Asl, Joshua Hague, Sudhakar Sivapalan, Wolfgang Maier, Mojca Z. Dernovsek, Neven Henigsberg, Joanna Hauser, Daniel Souery, Annamaria Cattaneo, Ole Mors, Marcella Rietschel, Gerald Pfeffer, Stacey Hume, Katherine J. Aitchison   +22 more
openaire   +8 more sources

Genotyping Streptococcus Pneumoniae [PDF]

Future Microbiology, 2015
Streptococcus pneumoniae is a potentially deadly human pathogen associated with high morbidity, mortality and global economic burden. The universally used bacterial genotyping methods are multilocus sequence typing and pulsed field gel electrophoresis.
Rayner, Rachael, Savill, John, Hafner, Louise, Huygens, Flavia   +3 more
openaire   +3 more sources

Genotyping of Campylobacter spp [PDF]

Applied and Environmental Microbiology, 2000
method. The major disadvantages of both of these techniques are the high number of untypeable strains and the time-consuming and technically demanding requirements of the techniques. Production and quality control of antiserum reagents for serotyping schemes are costly; consequently, these reagents are not widely available. A recently developed scheme (
T M, Wassenaar, D G, Newell
openaire   +2 more sources

Yersinia pestis Genotyping

Emerging Infectious Diseases, 2005
To the Editor: Drancourt et al. (1) report the development of an original genotyping system for Yersinia pestis based on intergenic spacer sequencing. However, the approach appears to rely upon the characterization of polymorphisms due to tandem repeat variation.
Didier Raoult, Michel Drancourt, Pierre Edouard Fournier, Hiro Ogata, Gilles Vergnaud   +4 more
openaire   +4 more sources

Genetic Variants in the Mitochondrial Thymidylate Biosynthesis Pathway Increase Colorectal Cancer Risk

Current Oncology, 2023
We assess the contributions of genetic variants for the enzymes involved in capecitabine metabolism to colorectal cancer (CRC) development risk. In this case-control study, DNA samples were collected from 66 patients (King Abdulaziz University Hospital ...
Entesar M. Arrait, Ayat B. Al-Ghafari, Huda A. Al Doghaither   +2 more
doaj   +1 more source

A new genotype ofArthroderma benhamiae [PDF]

Medical Mycology, 2008
Nucleotide sequence analysis of chitin synthase 1 (CHS1) indicated 90% sequence similarities among human and animal isolates of Arthroderma benhamiae. In particular, greater than 99% similarity was noted in the nucleotide sequence among Americano-European race isolates, African race isolates, and five isolates from four-toed hedgehogs (Atelerix ...
Rui, Kano, Ayako, Sano, Koichi, Makimura, Shinichi, Watanabe, Kazuko, Nishimura, Hideo, Yamaguchi, Atuhiko, Hasegawa   +6 more
openaire   +2 more sources

The Association of MMP7 Genotype With Pterygium [PDF]

In Vivo, 2019
In literature, few studies have examined the diagnostic or prognostic potential of matrix metalloproteinases (MMP) in pterygium, whose formation and progression are closely related to imbalance in the extracellular microenvironment. In this study, we investigated the contribution of MMP7 promoter (A-181G and C-153T) polymorphic genotypes to pterygium ...
Pei-Shin, Hu, Yun-Chi, Wang, Cheng-Hsi, Liao, Ning-Yi, Hsia, Meng-Feng, Wu, Jai-Sing, Yang, Chien-Chih, Yu, Wen-Shin, Chang, DA-Tian, Bau, Chia-Wen, Tsai   +9 more
openaire   +2 more sources

Genotypes and phenotypes ofDNM1encephalopathy

Journal of Medical Genetics, 2023
BackgroundVariants in the dynamin-1 (DNM1) gene typically cause synaptopathy, leading to developmental and epileptic encephalopathy (DEE). We aimed to determine the genotypic and phenotypic spectrum ofDNM1encephalopathy beyond DEE.MethodsElectroclinical phenotyping and genotyping of patients with aDNM1variant were conducted for patients undergoing next-
Jeehyun Kim, Lip-Yuen Teng, Bilal Shaker, Dokyun Na, Hyun Yong Koh, Soon Sung Kwon, Joon Soo Lee, Heung Dong Kim, Hoon-Chul Kang, Se Hee Kim   +9 more
openaire   +3 more sources