Results 261 to 270 of about 1,007,160 (300)

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

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APOEGenotype and Brain Development

JAMA Neurology, 2014
Theobservationthat inheritanceoftheapolipoproteinE(APOE) e4allelepredisposesdramaticallytoAlzheimerdisease(AD)was first reported in 19931 and has been replicated in hundreds of studies thereafter. It is oneof themost robust genetic associationswith common disease discovered in all ofmedicine, yet despite 20years of research, the reason thatAPOE e4has ...
John H, Growdon, Bradley T, Hyman
openaire   +2 more sources

ABCB1 Genotyping in the Treatment of Depression

Pharmacogenomics, 2016
P-glycoprotein (P-gp), the gene product of ABCB1, is a drug transporter at the blood-brain barrier and could be a limiting factor for entrance of antidepressants into the brain, the target site of antidepressant action. Animal studies showed that brain concentrations of many antidepressants depend on P-gp.
Brückl, T., Uhr, M.
openaire   +3 more sources

Oviposition in thePeriodGenotypes ofDrosophila Melanogaster

Chronobiology International, 1998
Two behavioral rhythm phenotypes, oviposition and locomotor activity, have been compared in the four period genotypes (per+, pers, per0, and per1) of Drosophila. Period, signal-to-noise ratio, and phase were all analyzed and the genetic penetrance of the two characters was estimated.
C, McCabe, A, Birley
openaire   +2 more sources

A genotype-directed study to optimize dosing of irinotecan according to the UGT1A1 genotype.

Journal of Clinical Oncology, 2013
2570 Background: The risk of severe neutropenia from irinotecan (I) is in part related to UGT1A1*28, a polymorphism that reduces the elimination of SN-38, the active metabolite of I. We aimed to identify the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of I in advanced solid tumor patients (pts) stratified by*1/*1, *1/*28, and *28 ...
Federico Innocenti, Ravi Salgia, Jacqueline Ramirez, Linda A. Janisch, Samir D. Undevia, Larry House, Soma Das, Kehua Wu, Michelle Turcich, Robert de Wilton Marsh, Theodore Karrison, Michael L. Maitland, Richard L. Schilsky, Mark J. Ratain   +13 more
openaire   +1 more source

CYP2D6 genotyping in an Argentinean population.

Journal of Clinical Oncology, 2014
e13543 Background: The polymorphic CYP2D6 gene shows a high degree of interindividual and interethnic variability that influences its expression and function.
Maria Florencia Gosso, Melisa Del federico, Analia Seravalle, Maria Sonia Baquedano, Fabian Fay   +4 more
openaire   +1 more source

A new inactivated BVDV genotype I and II vaccine An immunisation and challenge study with BVDV genotype I

Veterinary Microbiology, 2000
An inactivated vaccine containing BVDV I and II strains (PT810; BVDV I, and 890; BVDV II) and using different adjuvants and antigen dosages was tested in a cattle challenge model. Groups of six healthy, seronegative cattle were vaccinated twice with a low dose (10(6.6) TCID(50) PT810 and 10(7.2) TCID(50) 890) vaccine with the adjuvant Bay R1005 or a ...
M, Beer, H R, Hehnen, A, Wolfmeyer, G, Poll, O R, Kaaden, G, Wolf   +5 more
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Multiple Genotypes in Individuals of Claytonia virginica

Science, 1971
Supernumerary chromosomes are common among plants of Claytonia virginica found in a weedy population near the southwestern edge of its distribution. Roots, stems, and microsporocytes vary in chromosome number within the same plant in 68 percent of the population studied
W H, Lewis, R L, Oliver, T J, Luikart
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CYP3A4 and CYP3A5 Genotyping Recommendations

Journal of Molecular Diagnostics, 2023
The goals of the Association for Molecular Pathology Clinical Practice Committee's Pharmacogenomics (PGx) Working Group are to define the key attributes of pharmacogenetic alleles recommended for clinical testing and a minimum set of variants that should be included in clinical PGx genotyping assays.
Pratt, Victoria M., Cavallari, Larisa H., Fulmer, Makenzie L., Gaedigk, Andrea, Hachad, Houda, Ji, Yuan, Kalman, Lisa V., Ly, Reynold C., Moyer, Ann M., Scott, Stuart A., van Schaik, Ron H.N., Whirl-Carrillo, Michelle, Weck, Karen E.   +12 more
openaire   +1 more source

GENOTYPE × ENVIRONMENT INTERACTIONS FOR IN VITRO DIGESTIBILITY OF TIMOTHY (Phleum pratense L.) GENOTYPES

Canadian Journal of Plant Science, 1986
Improved in vitro digestibility (IVD) is an important goal in timothy (Phleum pratense L.) breeding. This study examines the effect of genotype × environment (GE) interactions on individual genotypes and examines two methods for identifying superior parental genotypes.
A. R. McELROY, B. R. CHRISTIE
openaire   +1 more source