Results 51 to 60 of about 55,860 (249)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Phenotypic variability analysis of key sorghum (Sorghum bicolor (L) moench) genotypes under dry lowland areas

Reproduction and Breeding
Sorghum is a climate-resilient food security and nutrition crop, which has been produced as a staple food in the semi-arid tropical regions of the world.
Temesgen Begna
doaj   +1 more source

Quantitative genetics of maize (Zea mays L.) during seedling establishment under cool conditions : a thesis presented in partial fulfillment of the requirements for the degree of Master of Agricultural Science in Plant Science at Massey University [PDF]

, 1992
Two experiments were conducted to study cool tolerance in maize (Zea mays L.). The first experiment was carried out under controlled environment to evaluate several genotypes from five synthetic populations which are currently being used to develop ...
Chozin, Mohammad
core  

Relationship Between Physiological Characteristic and Bean Quality on Some Cocoa Clones (Theobroma Cacao L.) [PDF]

, 2015
Photosynthesis is one of the physiological process that influence the bean weight and this process related with the efectiveness of the stomata character and chlorophyll content in the leaves.
Sari, I. A. (Indah), Susilo, A. W. (Agung), Zakariyya, F. (Fakhrusy)   +2 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic variability, heritability, correlation and path analysis in snake gourd (Trichosanthes cucumerina L.)

Electronic Journal of Plant Breeding, 2017
The present investigation was conducted to magnitude the genetic variability, heritability and genetic advance in snake gourd for identifying desirable parents. Fifty genotypes were evaluated for eleven characters through RBD during the year 2011–12. The
N. Deepa Devi, S. Mariappan, T. Arumugam and, C.R. Anandakumar   +3 more
doaj   +1 more source

Differential Functional Constraints Cause Strain-Level Endemism in Polynucleobacter Populations. [PDF]

, 2016
The adaptation of bacterial lineages to local environmental conditions creates the potential for broader genotypic diversity within a species, which can enable a species to dominate across ecological gradients because of niche flexibility.
Geeta Rijal, Herbert Ssegane, Iratxe Zarraonaindia, Jack A. Gilbert, Janet K. Jansson, Jarrad T. Hampton-Marcell, M. Cristina Negri, Naseer Sangwan, Tifani W. Eshoo   +8 more
core   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels [PDF]

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Ayoubi, T.A., Bruin, T.W., Feskens, E.J.M., Glembotski, C.C., Greevenbroek, M.M., Heldens, J., Hofker, M.H., Kallen, C.J., Kuusisto, J., Laakso, K., Meex, S.J., Pajukanta, P., Schalkwijk, C.G., Sinsheimer, J.S., Stehouwer, C.D., Taskinen, M.R., Thuerauf, D.J., Vlietinck, R., Weissglas-Volkov, D., Wouters, B.G.   +19 more
core   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source