Results 51 to 60 of about 22,130 (225)

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

GENETIC VARIABILITY, HERITABILITY AND GENETIC ADVANCE FOR POD YIELD AND ITS CONTRIBUTING TRAITS IN OKRA HYBRIDS

Madras Agricultural Journal, 1997
Genotypic coefficient of variation, heritability and genetic advance of pod yield and seven other traits were estimated in 40 Fi's of okra. The characters like number of branches, number of pods and total pod yield per plant had higher genotypic as well ...
P.K.PANDA and K.P.SINGH
doaj   +1 more source

Improving the Diagnostic Accuracy of Plasma Alzheimer's Disease Biomarkers With Objective and Subjective Cognitive Screening

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Blood‐based biomarkers are increasingly used to identify Alzheimer's disease (AD) pathology and may play an important role in early disease screening and participant selection for clinical trials. However, their performance across stages of cognitive impairment remains unclear. This study examined whether plasma biomarkers differ in
Maryam Abdolmaleki, Leslie S. Gaynor, Dandan Liu, Timothy J. Hohman, Katherine A. Gifford, Henrik Zetterberg, Angela L. Jefferson, Corey J. Bolton   +7 more
wiley   +1 more source

Assessment of Genetic Diversity and Heritability of Physiological and Phenological Characteristics of some Strawberry (Fragaria × ananassa Duch . ) Genotypes under Climatic Conditions of Kurdistan, Iran [PDF]

پژوهش‌های ژنتیک گیاهی
Strawberry (Fragaria × ananassa Duch . ) is one of the important and commercial small fruits that are planted in temperate regions which contain high amount of natural antioxidants .
Esmail Arab Tajandarreh, Ahmad Ismaili, Abdolhossein Rezaei Nejad, Farhad Karami   +3 more
doaj  

Exploring Genetic Variability, Trait Associations and Path Coefficient Analysis in Pea (Pisum sativum L.) to Advance Breeding Strategies

International Journal of Bio-Resource and Stress Management
The experiment was conducted at seed breeding farm, Department of Plant Breeding and Genetics, College of Agriculture, JNKVV, Jabalpur, Madhya Pradesh, India during the rabi season (November, 2019–April, 2020) to estimate the parameters of genetic ...
Kumar Jai Anand, S. K. Singh, Sachin Prakash Nagre, Sunny Thakur, Teena Patel, P. K. Moitra   +5 more
doaj   +1 more source

Genetic variability, correlation and path analysis for yield and yield components in F6 families of Greengram (Vigna radiata (L.) Wilczek) under rainfed condition.

Electronic Journal of Plant Breeding, 2016
An experiment was laid out on greengram to study the genetic variability among the yield and yield contributing characters. High genotypic coefficient of variation was exhibited by plant height followed by number of pods per plant and seed yield per ...
G. Anand, K. Anandhi and, V.K. Paulpandi
doaj   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Genetic variability, correlation and path coefficients of yield and its components analysis in pumpkin (Cucurbita moschata Duch Ex Poir)

International Journal of Agricultural Research, Innovation and Technology, 2017
Genetic variability, correlation and path coefficient were studied for yield and yield component traits in twenty one diverse genotypes of pumpkin. Highest genotypic coefficient of variation was recorded for fruit length (cm), single fruit weight (kg ...
GM Mohsin
doaj   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source