Results 251 to 260 of about 63,568 (308)

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Hybrid Horizons: Screening Hybridisation Through Nuclear Environmental DNA. [PDF]

Mol Ecol Resour
Zumel D, Didaskalou E, Vučić T, Cvijanović M, Ivanović A, Ajduković M, Wielstra B, Theodoropoulos A, Stewart K.   +8 more
europepmc   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Comparative phenotypic and genotypic analysis of distinct <i>Pseudomonas aeruginosa</i> T3SS effector genotypes. [PDF]

Front Cell Infect Microbiol
Alharbi NK, El-Sawy NA, Dahran NA, Atwah B, Al-Kushi AG, Alharbi M, Abdelkhalig SM, Mosbah RA, Mansour AT, Bendary MM.   +9 more
europepmc   +1 more source

A simple model captures key characteristics of biological non-deterministic genotype-phenotype maps. [PDF]

PLoS Comput Biol
Martin NS.
europepmc   +1 more source

Dissecting the yield architecture and selecting superior seedling-derived half-sib progenies of turmeric (<i>Curcuma longa</i> L.) through multi-trait selection indices. [PDF]

Front Plant Sci
Neeraja A, Mukesh Sankar S, Aarthi S, Yuvaraj KM, Prasath D.   +4 more
europepmc   +1 more source

Predictions of wheat phenotypic variability by integrating high-throughput phenotyping observations into a crop growth model. [PDF]

Plant Phenomics
Cai D, Zhu C, Wang X, Manceau L, Jezequel S, Marguerie M, de Solan B, Baret F, Buis S, Liu S, Martre P.   +10 more
europepmc   +1 more source

Phenotypic and Genotypic Detection of Extended-Spectrum Beta-Lactamase (ESBL) and Metallo-Beta-Lactamase (MBL) Genes in Multidrug-Resistant Acinetobacter baumannii Isolates Derived From Diabetic Foot Ulcer Patients. [PDF]

Cureus
Gupta HK, Karicheri R, Mehta A.
europepmc   +1 more source

Hearing loss and truncating variants in Alport syndrome. [PDF]

Kidney Res Clin Pract
Yim HE.
europepmc   +1 more source