Results 231 to 240 of about 612,806 (292)

HPV Genotypes and Survival Outcomes in Invasive Cervical Cancer: A Retrospective Molecular Analysis of FFPE Clinical Samples in an Iranian Cohort. [PDF]

Int J Womens Health
Darvishali MH, Nikkhah H, Rahavi H, Jalali H, Vakili Ghasem Abad M, Vajihinejad M, Farashahi-Yazd E.   +6 more
europepmc   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Associations of the <i>ICAM1</i> p.K56M HFpEF Risk Variant With Pericardial Adiposity and the Inflammatory Proteome. [PDF]

Circ Genom Precis Med
Aneja A, Culler KL, Ding J, Taylor KD, Shah SJ, Rasmussen-Torvik L, Patel RB.   +6 more
europepmc   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

fRagmentomics: an R package for integrating cell-free DNA fragment features with mutational status to support liquid biopsy interpretation. [PDF]

Bioinformatics
Maudet K, Samaniego J, Pradat Y, Bernard E.   +3 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

An automated plasma-based proteotyping immunoassay for APOE ε4 zygosity classification in Alzheimer's disease. [PDF]

Alzheimers Dement
Levin S, Engel B, Carlson C, Hinson J, Holland M, Figdore D, Lim HK, Tiers L, Bhatt K, Schlichtmann B, Hoffmann K, Bae YE, Szabo M, Lehmann S, Um YH, Algeciras-Schimnich A.   +15 more
europepmc   +1 more source

R263K-associated dolutegravir resistance on tenofovir, lamivudine and dolutegravir: Implications for earlier genotyping and regimen optimisation. [PDF]

S Afr J Infect Dis
Naidoo S.
europepmc   +1 more source

Performance of the ForenSeq^TM Imagen Kit for Forensic DNA Phenotyping Under Partial Genotyping Conditions. [PDF]

Genes (Basel)
González-Ortiz N, Guardado-Estrada M, Zepeta-Flores N, Moreno-Ortiz JM, Ramírez-de-Arellano A, Rangel-Villalobos H, Muñoz-Valle JF, Aguilar-Velázquez JA.   +7 more
europepmc   +1 more source