Results 271 to 280 of about 1,163,135 (344)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

First Data on the Occurrence and Genotyping of Enterocytozoon bieneusi in Wrestling Camels in Türkiye. [PDF]

Acta Parasitol
Simsek NS, Cakmak I, Simsek E.
europepmc   +1 more source

INCREASED DIHYDROFOLATE REDUCTASE SYNTHESIS IN DIPLOCOCCUS PNEUMONIAE FOLLOWING TRANSLATABLE ALTERATION OF THE STRUCTURAL GENE. I. GENOTYPE DERIVATION AND RECOMBINATIONAL ANALYSES

, 1969
Francis M. Sirotnak, Sandra L Hachtel
openalex   +2 more sources

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, EarlyView.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Utility of tryptase genotyping in the screening, diagnosis, and management of systemic mastocytosis. [PDF]

Front Allergy
McMurray JC, Schornack BJ, Villar J, George TI, Boggs NA.   +4 more
europepmc   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

Using Blood Group Genotyping to Predict Hemolysis in Patients With β-Thalassemia Major With Frequent Transfusions: Protocol for a Cross-Sectional Study.

JMIR Res Protoc
Indriani V, Triyono T, Mulyono B.
europepmc   +1 more source

Integrating parental genomes to reduce reference bias and identify intramuscular fat genes in Qinchuan Black pigs. [PDF]

J Anim Sci Biotechnol
Lv G, Yang P, Guo A, Cao M, Li D, Liu Z, Wang M, Sun J, Ding R, Yu T.   +9 more
europepmc   +1 more source

Genotype-Environment Interactions in Egg Production Stocks of Chickens

, 1969
H.L. MARKS, N.R. Gyles, H.R. Wilson, L.D. Tindell, William A. Johnson, L.J. Dreesen, W.L. Blow, W.F. Krueger, P.B. Siegel   +8 more
openalex   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source