Results 281 to 290 of about 782,061 (323)

CYP2C19 genotyping and mavacamten: predicting outcomes in normal, intermediate and rapid metabolisers in obstructive hypertrophic cardiomyopathy. [PDF]

Eur J Clin Pharmacol
Kasolo Y, Burford E, Obeidat M, Beaman GM, Monk T, Bastiaenen R, Newman WG, Cooper RM.   +7 more
europepmc   +1 more source

Genotype [PDF]

, 2019
openaire   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

No G6PD A- (G202A) variant detected among <i>Plasmodium falciparum</i>-positive patients in Awka, Southeast Nigeria: a hospital-based study. [PDF]

Malariaworld J
Ikegbunam M, Uchechukwu N, Abone H, Grace AE, Ezeunala M, Joy N, Immaculata NC, Igwe JO, Okeke O, Nworji F, Ihekwereme P.   +10 more
europepmc   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Utility of extended HPV genotyping in cervical cancer screening: a prospective population-based cohort study in China. [PDF]

Front Oncol
Yi K, Zhang J, Wang H, Chen P, Sun X, Li M, Zhang S.   +6 more
europepmc   +1 more source

A Genotype-phenotype Taxonomy of Hypertrophic Cardiomyopathy

Lara Curran, Antonio de Marvao, Paolo Inglese, Kathryn A. McGurk, Adam Clement, Sean L. Zheng, Surui Li, Chee Jian Pua, Mit Shah, Mina Jafari, Pantazis Theotokis, Rachel Buchan, Sean J. Jurgens, Claire E. Raphael, John Baksi, Antonios Pantazis, Brian P. Halliday, Dudley J. Pennell, Wenjia Bai, Calvin Chin, Rafik Tadros, Connie R. Bezzina, Hugh Watkins, Stuart A. Cook, Sanjay Prasad, James S. Ware, Declan P. O’Regan   +26 more
openalex   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Development of KASP markers, SNP fingerprinting and population structure analysis of <i>Robinia pseudoacacia</i> and its closely related species. [PDF]

Front Plant Sci
Wang H, Wang R, Zheng H, Zhao C, Zang D, Ma Y, Zang F, Wu Q.   +7 more
europepmc   +1 more source