Results 31 to 40 of about 3,783 (266)

3D‐Printed Porous Hydroxyapatite Formed via Enzymatic Mineralization

Advanced Functional Materials, EarlyView.
Bone combines lightness, strength, and the ability to heal, inspiring new materials design. This work introduces a room‐temperature, enzyme‐mediated 3D printing method to create porous hydroxyapatite scaffolds. The process avoids energy‐intensive sintering, preserves bioactivity, and allows control over porosity and mineralization.
Francesca Bono, Anna Puiggalí‐Jou, Greta Cocchi, Mariangela Miccoli, Katharina Maniura‐Weber, Marcy Zenobi‐Wong, Esther Amstad   +6 more
wiley   +1 more source

Hva er effekten av empirisk kombinasjonsbehandling med antibiotika sammenlignet med monoterapi for voksne pasienter med septisk sjokk forårsaket av ukjent patogen og ukjent opprinnelse: en systematisk oversikt [PDF]

, 2020
Innledning: De norske nasjonale retningslinjene fra 2013 for antibiotikabehandling av sepsis og septisk sjokk har blitt diskutert på grunn av usikkerhet omkring effekt og sikkerhet av nåværende anbefalt kombinasjonsbehandling.
Arentz-Hansen, Eva Helene, Giske, Liv, Himmels, Jan Peter William, Hval, Gyri, Vist, Gunn Elisabeth   +4 more
core  

Co‐Electrospinning Extracellular Matrix with Polycaprolactone Enables a Modular Approach to Balance Bioactivity and Mechanics of a Multifunctional Bone Wrap

Advanced Healthcare Materials, EarlyView.
The incorporation of nondigested ECM and synthetic polymers into a co‐electrospinning system enables the decoupling of bioactivity and mechanical properties within a single wrap. This technique is used to develop a multifunctional bone wrap that achieves augmented membrane durability, sustained infection control, and enhanced vascularity for use in ...
Sarah Jones, Madeline Laude, Zeenat Oyebanji, Ruchi Birur, Andres Luengo Martinez, Isabelle Gilbert, Phillip Baek, Nichole Longbottom, Nicole McCullough, Staci J. Horn, Chien‐Yu Lin, Matthew J. Lohr, Fred Clubb, Manuel K. Rausch, Elizabeth Cosgriff‐Hernandez   +14 more
wiley   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Speciation Studies of Biologically Active Compounds (Atomic Absorption, Ultrasonic Nebulization, Hplc, Organoleads, Aminoglycosides-Metal Complexes). [PDF]

, 1984
Part I. Development of a new nebulizer-flame atomizer atomic absorption system designed for metal speciation. A new flame atomic absorption system has been designed and developed.
Boothe, Edmund Douglas
core   +2 more sources

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

The Effect of Ampicillin and Gentamicin Conjugated with Gold Nanoparticles on the Formation of Biofilms in Pseudomonas aeruginosa

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives: Pseudomonas aeruginosa is a gram-negative bacterium and an opportunistic pathogen with several virulence factors. This bacterium is one of the common pathogens in nosocomial infections, particularly in patients with cystic ...
Ali Javadi, Mehdi Rostamirad, Mohammad Reza Zand Monfared, Fariba Dastjani Farahani, Azam Heidarpour, ohammad Khodadad Motlagh   +5 more
doaj  

In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides [PDF]

PURPOSE Single doses of gentamicin have demonstrated clinical efficacy in the treatment of urogenital gonorrhea, but lower cure rates for oropharyngeal and anorectal gonorrhea.
Crich, David, Gross, Sonja, Gysin, Marina, Herren, Sebastian, Hobbie, Sven N, Imkamp, Frank, Risch, Martin, Roditscheff, Anna, Rominski, Anna   +8 more
core   +1 more source

Characterization of two radical S-adenosyl-L-methionine enzymes in the biosynthesis of aminoglycosides [PDF]

, 2018
Biosynthetic studies of natural products are essential to the discovery and development of new drugs, because by understanding biosynthetic pathways and the enzymes that characterize them, new pathways can be engineered for the production of new ...
Kim, Hak Joong, active 21st century,
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source