Results 201 to 210 of about 1,901,326 (324)

Carrier‐Free Nanocapsule with Dual‐Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis

open access: yesAdvanced Science, EarlyView.
This manuscript presents a carrier‐free nanomedicine PCNPs@PEG‐Man with dual‐targeting for IBD. It resists harsh intestinal conditions, reduces oxidative stress, enhances drug uptake and retention, modulates inflammation, and reshapes gut microbiota, offering a safe and effective IBD therapy.
Yingjie Chen   +8 more
wiley   +1 more source

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

open access: yesAdvanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song   +37 more
wiley   +1 more source

Tactile Augmentation of Material Classification via Imperceptible On‐Skin Triboelectricity Collection

open access: yesAdvanced Science, EarlyView.
Human skin inherently forms a body‐coupled triboelectric circuit that enables the generation of triboelectric charges through contact between the skin surface and various materials. Integrated with an on‐finger, substrate‐free microfiber electrode, the material‐specific and personalized triboelectric signals can be imperceptibly collected for machine ...
Junting Huang   +7 more
wiley   +1 more source

Organization of the Proteostasis Network of Membraneless Organelles

open access: yesAdvanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim   +6 more
wiley   +1 more source

Novel opportunity of treatment for psycho-cardiologic disease by gut microbiome. [PDF]

open access: yesFront Cardiovasc Med
Lai Y   +7 more
europepmc   +1 more source

Auxin‐Producing Pseudomonas Recruited by Root Flavonoids Increases Rice Rhizosheath Formation through the Bacterial Histidine Kinase Under Soil Drying

open access: yesAdvanced Science, EarlyView.
Drought is a major cause of crop losses across agricultural regions. Rhizosheath formation enhances plant resistance to drought. Polyploids may tolerate stress more effectively through increased interactions with bacteria. However, the contributions of tetraploid rice associated microbiota to rhizosheath formation under soil drying remain unclear ...
Feiyun Xu   +23 more
wiley   +1 more source

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