Results 211 to 220 of about 1,991,563 (339)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Genus [PDF]

, 2008
openaire   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Distinct patterns of microbial association across deep-sea corals from the Western Pacific Magellan Seamounts. [PDF]

Microbiol Spectr
Song W, Zhang S, Perez M, Li J, Ma H, Thomas T, Qiu J-W, Qian P-Y.   +7 more
europepmc   +1 more source

A new genus and species of the Afrotropical Platynotina from Tanzania (Coleoptera: Tenebrionidae: Pedinini)

, 2013
Marcin Jan Kamiński
openalex   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

Species of the genus <i>Laureola</i> (Isopoda, Armadillidae), with an identification key to world species. [PDF]

Zookeys
Zong Z, Wang Y, Jiang C, Li W.
europepmc   +1 more source

Endogenospora, a new genus of anamorphic fungi from Venezuela

, 2010
Rafael F. Castañeda-Ruíz, Osmar Morillo, Belkis Tovar, Zulaima Hernández, Teresa Iturriaga, D. W. Minter, Josepa Gené, Josep Guarro, Marc Stadler   +8 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Proposal of two novel species, <i>Allocoprococcus similis</i> gen. nov., sp. nov. and <i>Faecalimonas hominis</i> sp. nov., isolated from human faeces and genome-based reorganization of the genus <i>Coprococcus</i>. [PDF]

Int J Syst Evol Microbiol
Yamamoto E, Hisatomi A, Miwa K, Sakurai N, Koizumi A, Ohkuma M, Tsuchihashi H, Sakamoto M.   +7 more
europepmc   +1 more source