A Complementarity‐Based Approach to De Novo Binder Design
Advanced Science, EarlyView.A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko +17 more
wiley +1 more source
The Occurrence and Bioactivities of <i>Amaryllidaceae</i> Alkaloids from Plants: A Taxonomy-Guided Genera-Wide Review. [PDF]
Plants (Basel)Lin GD, Vishwakarma P, Smith PN, Li RW.
europepmc +1 more source
The Dolichopodid Genus Nematoproctus Loew in North America [PDF]
, 1930 M. C. Van Duzee
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Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
Advanced Science, EarlyView.This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang +6 more
wiley +1 more source
Taxonomy, Phylogeny, Genomes, and Repeatomes in the Subgenera <i>Salvia</i>, <i>Sclarea</i>, and <i>Glutinaria</i> (<i>Salvia</i>, Lamiaceae). [PDF]
Int J Mol SciKalnyuk JV +6 more
europepmc +1 more source
Contributions towards a Knowledge of the Anatomy of the Genus Selaginella [PDF]
, 1902 R. J. Harvey‐Gibson
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Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Advanced Science, EarlyView.Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang +13 more
wiley +1 more source
Variations in oral health outcomes and mycobiome composition among COVID-19 convalescents. [PDF]
Sci RepTalaga-Ćwiertnia K +10 more
europepmc +1 more source
Description of a new genus and species of Coleoptera (family Hispidae) from New Britain
, 1904 David Sharp
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