Results 261 to 270 of about 1,098,194 (317)

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Tree Cover and Temperature Shape the Distribution of Epiphytic <i>Pleurozia</i> in Asia: Forest Havens in a Warming Climate. [PDF]

Ecol Evol
Huang L, Chen F, Su Y, Sun Z, Huang X, Lin H, Gao, Zhang L.   +7 more
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

A novel hexasegmented virus isolated from the phytopathogenic fungus Verticillium nonalfalfae. [PDF]

Arch Virol
Miljanić V, Sabanadzovic S, Aboughanem-Sabanadzovic N, Jakše J, Radišek S, Štajner N.   +5 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Microbial dynamics in gastric cancer: insights from full-length 16S rRNA nanopore sequencing in the MAGIC cohort. [PDF]

Front Microbiol
Zapata-Contreras D, Aldridge J, González-Puelma J, Navarrete M, Urrea C, Orellana F, Iriarte MJ, Delgado C, Puente M, Leiva L, Godoy L, Altamirano A, Karelovic S, Espinosa-Parrilla Y.   +13 more
europepmc   +1 more source

Leaf beetle diversity on a Southeast Asian continental island: Taxonomy, DNA barcoding, and preliminary evolutionary insights from Cat Ba Island, Vietnam. [PDF]

PLoS One
Nguyen DT, Ho LT.
europepmc   +1 more source

Extreme‐Thickness Meta‐Membrane for Controlling Terahertz Vectorial Beams

Advanced Science, EarlyView.
We propose ultra‐thin (λ/30) transmissive terahertz metasurfaces combining near‐field resonant and detour phases in coupled‐slit meta‐atoms, enabling continuous phase and polarization control beyond conventional designs. Based on leaky‐mode theory, scalar and vectorial terahertz Bessel beams at 0.39 THz are experimentally demonstrated, with ...
Yufei Song, Yixiang Xu, Yikai Xu, Yuanxi Liu, Shaojie Ma, Qiong He, Zhuo Wang, Lei Zhou   +7 more
wiley   +1 more source

Environmental Low Temperatures Dynamically Reshape the Microbial Diversity and Community Structure of the Vector Tick Haemaphysalis longicornis. [PDF]

Arch Insect Biochem Physiol
Pei T, Nwanade CF, Liang X, Zhang Y, Wang Z, Liu Z, Dai Y, Zhang X, Yu Z.   +8 more
europepmc   +1 more source

Phytochemical Profiling of <i>Sticta caulescens</i> De Not.: Green Extraction and Multiscale Chemotaxonomic Analysis. [PDF]

Plants (Basel)
Cifuentes-Araya N, Valdivia D, Pertino MW, Marroquín-Guerra D, Yáñez O, García-Beltrán O, Ardiles A, Areche C.   +7 more
europepmc   +1 more source