Results 121 to 130 of about 69,023 (286)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Preliminary geophysical interpretation of the McKeand River area, southern Baffin Island, Nunavut: insights from gravity, magnetic and geological data [PDF]

open access: yes
The recently completed McKeand River and Amittok Lake aeromagnetic surveys on southern Baffin Island, Nunavut pro- vide a new high-resolution magnetic dataset over an area with no previous coverage. Complemented by regional gravity data, newly acquired
St-Onge, Marc R.   +2 more
core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Tweeting in open public space : case study Belgrade [PDF]

open access: yes, 2017
Public spaces represent essential elements of vibrant, inclusive, and smart cities. Being attractive, safe, comfortable, active and sociable, open public spaces play the main role in revitalizing communities, supporting their sense of identity and ...
Dinkic, Nikola   +3 more
core   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Ptarmigan Fiord basement-cover thrust imbricates, Baffin Island, Nunavut [PDF]

open access: yes
The rocks at Ptarmigan Fiord on the Hall Peninsula of Baffin Island underwent midcrustal deformation during the formation of the Paleoproterozoic Trans-Hudson Orogen.
Carr, S D   +4 more
core  

Atomic Size Misfit for Electrocatalytic Small Molecule Activation

open access: yesAdvanced Functional Materials, EarlyView.
This review explores the application and mechanisms of atomic size misfit in catalysis for small molecule activation, focusing on how structural defects and electronic properties can effectively lower the energy barriers of chemical bonds in molecules like H2O, CO2, and N2.
Ping Hong   +3 more
wiley   +1 more source

Completing the bedrock mapping of southern Baffin Island, Nunavut; plutonic suites and regional stratigraphy [PDF]

open access: yes
This paper summarizes the field observations and initial interpretations following eight weeks of regional and targeted bed- rock mapping on south-central Baffin Island, Nunavut.
Dyck, B J   +4 more
core  

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