Results 151 to 160 of about 1,670,890 (327)
Advanced Science, EarlyView.Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang +9 more
wiley +1 more source
Revista de História, 1975 Formado em abril de 1974, numa iniciativa conjunta dos Centrosde Estudos Históricos Afonso d'Escragnolle Taunay e Estudos GeográficosCapistrano de Abreu, o grupo conta hoje com cerca de 30 elementos,alunos e tambem professores da Universidade de São Paulo.
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Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
VI. Part of letter from the Reverend Mr. Geo. Costard to Mr. John Catlin, concerning a fiery meteor seen in the air on July 14. 1745 [PDF]
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Advanced Science, EarlyView.This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding +14 more
wiley +1 more source
PRDM16 Reduces Cellular Senescence by Upregulating GSTM1
Advanced Science, EarlyView.Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan +7 more
wiley +1 more source
The Coming Ice Age . By C. A. M. Taber. Geo. H. Ellis. 1896. Pp. 94. [PDF]
, 1897 G. Frederick Wright
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