Results 191 to 200 of about 1,833,442 (372)

Coral geo-história

Revista de História, 1975
Formado em abril de 1974, numa iniciativa conjunta dos Centrosde Estudos Históricos Afonso d'Escragnolle Taunay e Estudos GeográficosCapistrano de Abreu, o grupo conta hoje com cerca de 30 elementos,alunos e tambem professores da Universidade de São Paulo.
openaire   +4 more sources

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

CCL5hi Macrophages Interact with CD8+ T Cells and Potentiate Responsiveness to PD‐1 Blockade Plus Chemotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study has characterized a functionally distinct macrophage subset, termed CCL5hi macrophages, and elucidated the underlying mechanisms of a regulatory feedback loop that interconnects IFN‐γ, CCL5hi macrophages, and CD8+ T cells within the TME of ESCC undergoing immunochemotherapy.
Yuanzhen Ma, Xiaodong Su, Tingting Zeng, Chunlian Zhou, Guozhen Yang, Zengfei Xia, Chufeng Zeng, Jiarong Zhan, Xin‐Yuan Guan, Xu Zhang, Yan Li   +10 more
wiley   +1 more source

Host genotype, soil composition, and geo-climatic factors shape the fonio seed microbiome [PDF]

Naheed Tabassum, Hanin Ibrahim Ahmed, Sabiha Parween, Arsheed H. Sheikh, Maged M. Saad, Simon G. Krattinger, Heribert Hirt   +6 more
openalex   +1 more source

Geo-Hazard Susceptibility Assessment and Its Impacts on Livelihoods in Kerio Valley, Kenya

, 2022
Mark Boitt, John Gathoni
openalex   +2 more sources

Characteristics of Infrastructure and Surrounding Geo-Environmental Circumstances Involved in Fatal Incidents Caused by Flash Flooding: Evidence from Greece [PDF]

, 2022
Michalis Diakakis
openalex   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Cost–benefit analysis for commissioning decisions in GEO 600 [PDF]

, 2015
T. Adams, J. R. Leong, J. Slutsky, M. Wąs, C. Affeldt, J. Degallaix, K. L. Dooley, H. Grote, S. Hild, H. Lück, D. M. Macleod, L. K. Nuttall, M. Prijatelj, E. Schreiber, B. Sorazu, K. A. Strain, P. J. Sutton, H. Vahlbruch, H. Wittel, K. Danzmann   +19 more
openalex   +1 more source