Results 231 to 240 of about 1,833,442 (372)

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

Geo-electrical investigation for groundwater potential of Ihievbe Ogben, Edo North, south western Nigeria

, 2018
S. A. Salami, A Ogbamikhumi
openalex   +2 more sources

Internet of Things Node with Real-Time LoRa GEO Satellite Connectivity for Agrifood Chain Tracking in Remote Areas. [PDF]

Sensors (Basel)
Giannetti G, Badii M, Lasagni G, Maddio S, Collodi G, Righini M, Cidronali A.   +6 more
europepmc   +1 more source

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

Advanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu, Liting Huang, Suzhen Bi, WeiKaixin Kong, Wanting Feng, Yingjia Li, Zhengwei Xie, Peipei Shan, Sujie Zhu   +8 more
wiley   +1 more source

Identification and validation of aryl hydrocarbon receptor-associated hub genes in ulcerative colitis via integrated bioinformatics analysis. [PDF]

Hum Genomics
Zhao Y, Wang J, Min X, Jiang F, Shi K, Liu H, Hu Y, Li W, Li W.   +8 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

A generalized supervised classification scheme to produce provincial wetland inventory maps: an application of Google Earth Engine for big geo data processing [PDF]

, 2019
Meisam Amani, Brian Brisco, Majid Afshar, S. Mohammad Mirmazloumi, Sahel Mahdavi, Sayyed Mohammad Javad Mirzadeh, Weimin Huang, Jean Granger   +7 more
openalex   +1 more source

Differential expression of glycolysis-related genes and their potential immune mechanisms in acute myocardial infarction. [PDF]

J Cardiothorac Surg
Li YM, Zhang KZ, Li QH, Qian YR, Li JW, Gao W, Zhou BJ.   +6 more
europepmc   +1 more source

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

Advanced Science, EarlyView.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong, Zhen Guo, Yu‐Lan Ma, Ming‐Yu Wang, Hai‐Yang Ni, Pan Wang, Wen‐Jun Qiu, En‐Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi‐Zhu Tang   +11 more
wiley   +1 more source

A Combination of Landsat-8 Satellite Imaging with Geothermal Manifestation Point at Wayratai Geothermal Prospect Area to identify “the zone of interest” on Geo-track and Geo-tourism planning

, 2020
Taufiq Taufiq, Maharani Maharani
openalex   +1 more source