Results 91 to 100 of about 317,036 (308)

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li   +6 more
wiley   +1 more source

Modeling Terrestrial Net Ecosystem Exchange Based on Deep Learning in China

open access: yesRemote Sensing
In estimating the global carbon cycle, the net ecosystem exchange (NEE) is crucial. The understanding of the mechanism of interaction between NEE and various environmental factors of ecosystems has been very limited, and the interactions between the ...
Zeqiang Chen   +3 more
doaj   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

open access: yesAdvanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang   +13 more
wiley   +1 more source

AI‐Driven Defecation Analysis by Smart Healthcare Toilet: Exploring Biometric Patterns and Eu‐Tenesmus

open access: yesAdvanced Science, EarlyView.
A healthcare toilet system is introduced to passively measure defecation behavior. Real‐time data on stool dropping duration, thickness, and a newly defined “eu‐tenesmus” interval show correlations with stool form and gender differences. Results from 45 defecation events reveal a promising method for comprehensive defecation analysis.
Zhiquan Song   +16 more
wiley   +1 more source

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

open access: yesAdvanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia   +39 more
wiley   +1 more source

Helicobacter pylori Detection Based on Synergistic Electromagnetic and Chemical Enhancement of Surface‐Enhanced Raman Scattering in 3D Hotspot‐Activated Gold Nanorods/Nano Mica Platelets/ZnO Quantum Dots

open access: yesAdvanced Science, Volume 12, Issue 28, July 24, 2025.
Gold nanorods hybridized with nano mica platelets and ZnO quantum dots are used for the rapid, sensitive, selective, and reproducible surface‐enhanced Raman scattering‐based detection of Helicobacter pylori in different scenarios. The origin of this high performance is ascribed to the synergy between the three operational enhancement mechanisms and the
Ming‐Chang Lu   +3 more
wiley   +1 more source

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