Results 131 to 140 of about 78,148 (290)

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Analysis of Surface Urban Heat Island in the Guangzhou-Foshan Metropolitan Area Based on Local Climate Zones

Land
Understanding the driving mechanisms behind surface urban heat island (SUHI) effects is essential for mitigating the degradation of urban thermal environments and enhancing urban livability.
Xiaxuan He, Qifeng Yuan, Yinghong Qin, Junwen Lu, Gang Li   +4 more
doaj   +1 more source

Telomere‐to‐Telomere Genomes Reveal that Multiscale Evolution Shapes the Largest Metabolic Arsenal of Diaporthe Fungi

Advanced Science, EarlyView.
This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li, Chen Zhang, Zhichao Zhang, Jiaheng Cheng, Qiuyan Gao, Long Gao, Xiaolin Zhao, Wei Yan, Yuanchao Wang, Wenwu Ye   +9 more
wiley   +1 more source

Disentangling the Roles of Climate Variables in Forest Fire Occurrences in China

Remote Sensing
In the context of global warming, climate strongly affects forest fires. With long-term and strict fire prevention policies, China has become a unique test arena for comprehending the role of climatic variables in affecting forest fires.
Chenqin Lian, Zhiming Feng, Hui Gu, Beilei Gao   +3 more
doaj   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Spatial and Temporal Evolution Pattern of Water Conservation Function of Ningxia Province and Its Attribution Analysis

Shuitu Baochi Xuebao
［Objective］ To assess the water conservation capacity of the upper Yellow River region, and to provide a scientific basis for the ecological protection and high-quality development of the Yellow River basin.
WANG Peng, MA Yilun, CHENG Jing, XU Mingxiang, SU Shengliang, PU Yong, HAN Lei, YANG Fang   +7 more
doaj   +1 more source

Identifying Driving Forces of Built-Up Land Expansion Based on the Geographical Detector: A Case Study of Pearl River Delta Urban Agglomeration. [PDF]

Int J Environ Res Public Health, 2020
Liu Y, Cao X, Li T.
europepmc   +1 more source

PM10 Impairs CD56dim NK Cell Cytotoxicity via FNBP1 Suppression to Exacerbate Rheumatoid Arthritis: Insights from Multimodal Multi‐Omics

Advanced Science, EarlyView.
This study, through multi‐omics approaches and animal models, revealed that air pollutant PM10 exacerbates the progression of rheumatoid arthritis (RA) by suppressing FNBP1 expression and impairing the cytotoxic function of CD56dim NK cells. The “PM10–FNBP1–NK cells” axis provided novel insights into the environmental pathogenesis of RA and suggested ...
Runhan Zhao, Qinyang Zhang, Yu Jiang, Dagang Tang, Xiao Qu, Jun Zhang, Yi Chen, Weixia Duan, Tao Li, Zhengwei Cai, Yanran Huang, Xiaoji Luo   +11 more
wiley   +1 more source

Study on the trade-off/synergy spatiotemporal benefits of ecosystem services and its influencing factors in hilly areas of southern China

Frontiers in Ecology and Evolution
IntroductionThis study aims to investigate the factors influencing ecosystem service trade-offs/synergies (TOSs) in major agricultural production areas in the southern hilly region and to propose optimization strategies to promote ecosystem ...
Fenglian Tan, Fenglian Tan, Zhaoyan Lu, Zhaoyan Lu, Fusheng Zeng, Fusheng Zeng   +5 more
doaj   +1 more source