Results 61 to 70 of about 64,153 (247)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The "Horizon-T" Experiment: Extensive Air Showers Detection [PDF]

, 2016
Horizon-T is an innovative detector system constructed to study Extensive Air Showers (EAS) in the energy range above 10^16 eV coming from a wide range of zenith angles (0 - 85 degrees). The system is located at Tien Shan high-altitude Science Station of
Baigarin, K. A., Beisembaev, R. U., Beisembaeva, E. A., Beznosko, D., Dalkarov, O. D., Ryabov, V. A., Sadykov, T. X., Stepanov, A. V., Suleymenov, N. S, Vildanov, N. G., Vildanova, M. I., Zhukov, V. V.   +11 more
core   +2 more sources

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Spatio-Temporal Evolution of Net Ecosystem Productivity and Its Influencing Factors in Northwest China, 1982–2022

Agriculture
The carbon cycle in terrestrial ecosystems is a crucial component of the global carbon cycle, and drought is increasingly recognized as a significant stressor impacting their carbon sink function.
Weijie Zhang, Zhichao Xu, Haobo Yuan, Yingying Wang, Kai Feng, Yanbin Li, Fei Wang, Zezhong Zhang   +7 more
doaj   +1 more source

Evaluation of the discovery potential of an underwater Mediterranean neutrino telescope taking into account the estimated directional resolution and energy of the reconstructed tracks

, 2012
We report on the development of search methods for point-like and extended neutrino sources, utilizing the tracking and energy estimation capabilities of an underwater, Very Large Volume Neutrino Telescope (VLVnT).
A. Leisos, A.G. Tsirigotis, Abassi, Agrawal, Braun, Grieder, Kappes, Neunhoffer, S.E. Tzamarias, Tsirigotis, Tsirigotis, Vissani, Vissani, Wentz, Zirakashvili   +14 more
core   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Analysis of the Trade-Off/Synergy Effect and Driving Factors of Ecosystem Services in Hulunbuir City, China

Agronomy
An in-depth understanding of the spatiotemporal heterogeneity of ecosystem service (ES) trade-offs and synergies, along with their driving factors, is crucial for formulating key ecological restoration strategies and effectively allocating ecological ...
Shimin Wei, Jian Hou, Yan Zhang, Yang Tai, Xiaohui Huang, Xiaochen Guo   +5 more
doaj   +1 more source

Background estimation in a wide-field background-limited instrument such as Fermi GBM

, 2012
The supporting instrument on board the Fermi Gamma-ray Space Telescope, the Gamma-ray Burst Monitor (GBM) is a wide-field gamma-ray monitor composed of 14 individual scintillation detectors, with a field of view which encompasses the entire unocculted ...
Briggs, Michael, Connaughton, Valerie, Fitzpatrick, Gerard, McBreen, Sheila, Team, the GBM   +4 more
core   +1 more source