PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Introducing the Spatial Conflict Dynamics indicator of political violence
, 2020 Modern armed conflicts have a tendency to cluster together and spread geographically. However, the geography of most conflicts remains under-studied. To fill this gap, this article presents a new indicator that measures two key geographical properties of
Radil, Steven M. +3 more
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Ecosystem‐Centered Robot Design: Toward Ecoresorbable Sustainability Robots (ESRs)
Advanced Science, EarlyView.Robots exploring natural ecosystems can support monitoring and conservation, but must adopt ecosystem‐centered design to avoid pollution, waste, and damage. This review proposes guidelines for co‐designing ecoresorbable sustainability robots (ESRs), uniting materials, robotics, and ecological contexts in a single framework.
Tülin Yılmaz Nayır +4 more
wiley +1 more source
Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes
Advanced Science, EarlyView.Patescibacteriota represents a diverse group of ultra‐small epibiotic bacteria, which is largely overlooked. By integrating ribosomal protein S3‐based community profiling with MAG‐based metabolic potential analyses, this study provides new insights into their distribution, diversity, and potential interactions with other bacteria across diverse ...
Yanhan Ji +12 more
wiley +1 more source
Mapping the geographical distribution of yaws
The Lancet Global Health, 2015 David Mabey
doaj +1 more source
Description of a new Crossidius LeConte (Coleoptera: Cerambycidae: Cerambycinae: Trachyderini) from southern Georgia with comments on its biology and unusual distribution [PDF]
, 2013 Crossidius grahami Morris and Wappes new species (Coleoptera: Cerambycidae) is described from the Ohoopee Dunes of southern Georgia. Comments are included on the new species’ biology and disjunct distribution compared to other species of Crossidius ...
Morris, Roy F., Wappes, James E.
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Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques
Advanced Science, EarlyView.Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang +12 more
wiley +1 more source
Mapping Sectoral Patterns of Technological Accumulation into the Geography of Corporate Locations. A Simple Model and Some Promising Evidence [PDF]
Economies of agglomeration are central in understanding the emergence of industrial clustering. However, existing models that incorporate economies of agglomeration to explain industrial concentration have been providing a quite small set of empirically ...
Giorgio Fagiolo +2 more
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Knowledge, Innovation and Agglomeration - regionalized multiple indicators and evidence from Brazil [PDF]
, 2005 This paper develops multiple indicators to map the geographical distribution of knowledge and scientific and technological capabilities as proxies of the geographical distribution of Science, Technology & Innovation activities, and applies such ...
Furtado, Joao +3 more
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MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts
Advanced Science, EarlyView.We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang +5 more
wiley +1 more source