Results 51 to 60 of about 525,446 (285)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Efficient simplicial replacement of semialgebraic sets
Forum of Mathematics, Sigma, 2023 Designing an algorithm with a singly exponential complexity for computing semialgebraic triangulations of a given semialgebraic set has been a holy grail in algorithmic semialgebraic geometry. More precisely, given a description of a semialgebraic set
Saugata Basu, Negin Karisani
doaj +1 more source
GeoSay: A Geometric Saliency for Extracting Buildings in Remote Sensing Images
, 2018 Automatic extraction of buildings in remote sensing images is an important but challenging task and finds many applications in different fields such as urban planning, navigation and so on. This paper addresses the problem of buildings extraction in very
Huang, Jin +4 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Rounding Algorithms for a Geometric Embedding of Minimum Multiway Cut
, 2003 The multiway-cut problem is, given a weighted graph and k >= 2 terminal nodes, to find a minimum-weight set of edges whose removal separates all the terminals.
Karger, David +4 more
core +3 more sources
Geometric Computations on Indecisive Points [PDF]
, 2011 We study computing with indecisive point sets. Such points have spatial uncertainty where the true location is one of a finite number of possible locations. This data arises from probing distributions a few times or when the location is one of a few locations from a known database.
Jørgensen, Allan Grønlund +2 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Journal of Industrial Engineering International, 2018 Acyclic phase-type distributions form a versatile model, serving as approximations to many probability distributions in various circumstances. They exhibit special properties and characteristics that usually make their applications attractive.
Mohsen Varmazyar +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source