Results 51 to 60 of about 966,408 (295)

The importance of mechanical constraints for proper polarization and psuedo-cleavage furrow generation in the early Caenorhabditis elegans embryo. [PDF]

PLoS Computational Biology, 2018
Intracellular polarization, where a cell specifies a spatial axis by segregation of specific factors, is a fundamental biological process. In the early embryo of the nematode worm Caenorhabditis elegans (C.
Betül Senay Aras, Y C Zhou, Adriana Dawes, Ching-Shan Chou   +3 more
doaj   +1 more source

Body-and-cad geometric constraint systems [PDF]

Proceedings of the 2009 ACM symposium on Applied Computing, 2009
Motivated by constraint-based CAD software, we develop the foundation for the rigidity theory of a very general model: the body-and-cad structure, composed of rigid bodies in 3D constrained by pairwise coincidence, angular and distance constraints. We identify 21 relevant geometric constraints and develop the corresponding infinitesimal rigidity theory
Haller, Kirk, Lee-St.john, Audrey, Sitharam, Meera, Streinu, Ileana, White, Neil   +4 more
openaire   +7 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Simple motion pursuit differential game problem of many players with integral and geometric constraints on controls function.

Journal of Nigerian Society of Physical Sciences, 2021
We study a simple motion pursuit differential game of many pursuers and one evader in a Hilbert space $l_{2}$. The control functions of the pursuers and evader are subject to integral and geometric constraints respectively.
Jamilu Adamu, B. M. Abdulhamid, D. T. Gbande, A. S. Halliru   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Multi-Constrained Optimization Method of Line Segment Extraction Based on Multi-Scale Image Space

ISPRS International Journal of Geo-Information, 2019
Image-based line segment extraction plays an important role in a wide range of applications. Traditional line segment extraction algorithms focus on the accuracy and efficiency, without considering the integrity.
Yiyuan Sun, Qiang Wang, Kevin Tansey, Sana Ullah, Fan Liu, Haimeng Zhao, Lei Yan   +6 more
doaj   +1 more source

Unified structural optimization method using topology optimization and genetic algorithms

Mechanical Engineering Journal, 2021
This paper presents a new structural design framework that incorporates the concept of topology optimization and genetic algorithms to improve the manufacturability and structural robustness of the optimal structure. The level set function is employed as
DoeYoung HUR, Sunghoon LIM, Kazuhiro IZUI, Shinji NISHIWAKI   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Unified Singularity Modeling and Reconfiguration of 3rT Metamorphic Parallel Mechanisms with Parallel Constraint Screws

Advances in Mechanical Engineering, 2015
This paper presents a unified singularity modeling and reconfiguration analysis of variable topologies of a class of metamorphic parallel mechanisms with parallel constraint screws.
Yufeng Zhuang, Dongming Gan
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source