Results 41 to 50 of about 220,947 (263)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Probability of ruin in discrete insurance risk model with dependent Pareto claims
Dependence Modeling, 2019 We present basic properties and discuss potential insurance applications of a new class of probability distributions on positive integers with power law tails.
Constantinescu Corina D. +2 more
doaj +1 more source
Machines, 2022 The small-size threaded connection is one of the main connection methods for complex and precision electromechanical products such as aerospace equipment.
Yang Yang +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
STUDY ON MODELING AND VISUALIZING THE POSITIONAL UNCERTAINTY OF REMOTE SENSING IMAGE [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016 It is inevitable to bring about uncertainty during the process of data acquisition. The traditional method to evaluate the geometric positioning accuracy is usually by the statistical method and represented by the root mean square errors (RMSEs) of ...
W. Jiao, T. Long, S. Ling, G. He
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Dizhen xuebao走滑断裂系的几何复杂段落可以影响大地震破裂的起始、扩展和结束，并最终决定了大地震破裂的长度和最大震级。四川宁南至云南巧家一带为青藏高原东边界则木河、大凉山和小江断裂的交会区，针对三条断裂曾开展过1 ∶ 5万活动断层填图工作，但对三条断裂的交切关系认识仍不充分，并且缺乏从断层系统的角度认识该地区断裂的几何展布和运动特征。本文针对断裂交会区开展了航片解译及详细的地质地貌调查，识别出小江断裂北段的走向在巧家以北发生约25°的偏转，形成了一个明显的弯曲构造；宁南盆地构成了则木河断裂和小江断裂的分段边界，为宽约4.
Mingming Wang, Han Chen, Sheng Li
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Spatial distribution of preantral follicles in the equine ovary. [PDF]
PLoS ONE, 2018 Comprehensive studies on spatial distribution of preantral follicles in the ovary are scarce. Considering that preantral follicles represent the main ovarian reserve, harvesting of these follicles is crucial for the development/use of assisted ...
Benner G Alves +5 more
doaj +1 more source