Results 31 to 40 of about 19,509 (258)

Dual-Time Topological Geometry and the Emergence of Temporal Asymmetry in Non-Equilibrium Dynamics

Mathematics
We develop a dual-time topological framework for the mathematical description of non-equilibrium systems, aimed at reconciling time-reversible microscopic dynamics with irreversible macroscopic behavior.
Mohamed Haj Yousef
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Bianchi Type I Cosmological Models in Eddington-inspired Born–Infeld Gravity

Galaxies, 2014
We consider the dynamics of a barotropic cosmological fluid in an anisotropic, Bianchi type I space-time in Eddington-inspired Born–Infeld (EiBI) gravity.
Tiberiu Harko, Francisco S.N. Lobo, Man Kwong Mak   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

On Geometric-Analytic Aspects of Solvable Nonlinear Ordinary Differential Equations and Some Applications

Mathematics
A geometric-analytic approach to studying invariants of solvable nonlinear ordinary differential equations is developed. In particular, there is described in detail a general scheme of constructing solvable nonlinear ordinary differential equations ...
Anatolij K. Prykarpatski, Victor A. Bovdi, Petro Y. Pukach, Yarema A. Prykarpatsky, Myroslava I. Vovk   +4 more
doaj   +1 more source

Dynamical system analysis of self-interacting three-form field cosmological model: stability and bifurcation

European Physical Journal C: Particles and Fields, 2021
The present work deals with Cosmological model of a three-form field, minimally coupled to gravity and interacting with cold dark matter in the background of flat FLRW space-time. By suitable choice of the dimensionless variables, the evolution equations
Soumya Chakraborty, Sudip Mishra, Subenoy Chakraborty   +2 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Cosmological implications of the Weyl geometric gravity theory

European Physical Journal C: Particles and Fields
We consider the cosmological implications of the Weyl geometric gravity theory. The basic action of the model is obtained from the simplest conformally invariant gravitational action, constructed, in Weyl geometry, from the square of the Weyl scalar, the
Tiberiu Harko, Shahab Shahidi
doaj   +1 more source