Results 71 to 80 of about 274,651 (285)
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
BIO Web of Conferences, 2016 We propose a muscle chemo-mechanical model by which myosin heads - that can chemically bind to actin, thus creating so-called cross-bridges producing contraction forces in sarcomeres at the subcellular level - are considered as special chemical entities ...
Chapelle Dominique
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti +19 more
wiley +1 more source
European Physical Journal C: Particles and Fields, 2023 We consider dark energy models obtained from the general conformal transformation of the Kropina metric, representing an $$(\alpha , \beta )$$ ( α , β ) -type Finslerian geometry, constructed as the ratio of the square of a Riemannian metric $$\alpha ...
Rattanasak Hama +2 more
doaj +1 more source
A geometric tangential approach to sharp regularity for degenerate evolution equations [PDF]
Analysis & PDE, 2014 That the weak solutions of degenerate parabolic pdes modelled on the inhomogeneous $p-$Laplace equation $$ u_t - \mathrm{div} \left(|\nabla u|^{p-2} \nabla u \right) = f \in L^{q,r}, \quad p>2 $$ are $C^{0,\alpha}$, for some $\alpha \in (0,1)$, is known for almost 30 years. What was hitherto missing from the literature was a precise and sharp knowledge
Teixeira, Eduardo, Urbano, José
openaire +3 more sources
Arthritis Care &Research, EarlyView.Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner +14 more
wiley +1 more source
Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control
Advanced Engineering Materials, EarlyView.This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian +4 more
wiley +1 more source
Postbuckling Investigations of Piezoelectric Microdevices Considering Damage Effects
Sensors, 2014 Piezoelectric material has been emerging as a popular building block in MEMS devices owing to its unique mechanical and electrical material properties. However, the reliability of MEMS devices under buckling deformation environments remains elusive and ...
Zhigang Sun, Xianqiao Wang
doaj +1 more source
Nonholonomic Ricci Flows: II. Evolution Equations and Dynamics
, 2008 This is the second paper in a series of works devoted to nonholonomic Ricci flows. By imposing non-integrable (nonholonomic) constraints on the Ricci flows of Riemannian metrics we can model mutual transforms of generalized Finsler-Lagrange and Riemann ...
Belinski V. A. +10 more
core +1 more source
Advanced Engineering Materials, EarlyView.Laser surface texturing significantly improves the corrosion resistance and mechanical strength of 3D‐printed iron polylactic acid (Ir‐PLA) for marine applications. Optimal laser parameters reduce corrosion by 80% and enhance tensile strength by 25% and ductility by 15%.
Mohammad Rezayat +6 more
wiley +1 more source