Results 201 to 210 of about 1,144,491 (344)

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

open access: yesBritish Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand   +8 more
wiley   +1 more source

Craniofacial Dysmorphology Associated With Phelan–McDermid Syndrome Using Three‐Dimensional Morphometrics

open access: yesClinical Genetics, EarlyView.
Using 3D morphometrics quantifies genetic contribution to head and face development. ABSTRACT Phelan–McDermid syndrome (PMS) frequently presents with distinctive facial features, although a typical facial phenotype for this condition has not been well characterized.
Katherine Weisensee   +6 more
wiley   +1 more source

Homo luzonensis and the role of homoplasy in the morphology of hominin insular species

open access: yesCladistics, EarlyView.
Abstract Homo luzonensis lived during the upper Pleistocene in the northern Philippines, east of the Wallace line. The few specimens attributed to this species show a mosaic of plesiomorphies for the genus Homo and apomorphies found in upper Pleistocene Homo species.
Pierre Gousset   +4 more
wiley   +1 more source

Flooding affects fluctuating asymmetry but not growth of a riparian orbweaving spider

open access: yesEcological Entomology, EarlyView.
In a mesocosm experiment we assessed the impact of flood on aquatic insect emergence and on spider development using geometric morphometric analysis of fluctuating asymmetry. We observed 45% higher emergence in flooded mesocosm throughout the season. Spiders did not grow bigger but exhibited ~15% lower fluctuating asymmetry than in controls.
Stephane Mutel   +10 more
wiley   +1 more source

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