Results 31 to 40 of about 879,303 (290)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

Angular momentum redirection phase of vector beams in a non-planar geometry

open access: yesNanophotonics, 2021
An electric field propagating along a non-planar path can acquire geometric phases. Previously, geometric phases have been linked to spin redirection and independently to spatial mode transformation, resulting in the rotation of polarisation and ...
McWilliam Amy   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Digital Protractor Integration in PhET Simulation for Proving Snell's Law in Mirror Geometric Optics: An Exploratory Study and Measuring Conceptual Understanding

open access: yesPhysics Communication
Technological developments are driving the transformation of science learning, including physics, from conventional to digital-based approaches. This study examines the use of a digital protractor in PhET simulations to verify Snell's Law (the law of ...
Najmah Nur Kamilah, Siti Wahyuni
doaj   +1 more source

Quasi-isotropic approximation of geometric optics [PDF]

open access: yes, 1969
Modified geometric optics method for solution of Maxwell ...
Kravtsov, Yu. A.
core  

Geometric optics in the presence of axionlike particles in curved spacetime

open access: yes, 2020
Schwarz D, Goswami J, Basu A. Geometric optics in the presence of axionlike particles in curved spacetime. Physical Review D. 2020;103(8): L081306.We present a concise derivation of geometric optics in the presence of axionic fields in a curved spacetime.
Basu, Aritra   +5 more
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

An introduction to Eulerian Geometrical Optics (1992-2002) [PDF]

open access: yes, 2002
This document is an attempt at introducing the different «Eulerian» numerical methods which have recently been developed for the simulation of geometric optics and related ...
Benamou, Jean-David
core   +1 more source

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