Results 41 to 50 of about 146,753 (263)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Geometric Morphometric Dataset of Edo-Period ‘Ogame’ Jar Profiles from Northern Kyushu, Japan

Journal of Open Archaeology Data
This dataset contains 243 silhouette images of Edo-period Ogame (“large jar”) vessels from Hizen and Chikuzen Provinces (modern-day Saga and Fukuoka prefectures), Japan.
James Frances Loftus
doaj   +1 more source

EHP Spectra and Periodicity. I: Geometric Constructions [PDF]

Transactions of the American Mathematical Society, 1993
This paper [and its second part, ibid. 340, 617-640 (1993; Zbl 0820.55006) below] attempts a new inductive construction of the Smith-Toda spectra \(V(m)\) and higher order EHP spectra. The problem is approached from an unstable point of view, using EHP sequences and formulating properties of a conjectured unstable filtration whose existence would lead ...
openaire   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Research on Preload and Stress Distribution of Small-Size Precision Threaded Connection Considering Geometric Deviation

Machines, 2022
The small-size threaded connection is one of the main connection methods for complex and precision electromechanical products such as aerospace equipment.
Yang Yang, Bo Yuan, Qingchao Sun, Xiaokai Mu, Binbin Zhao   +4 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

An empirical data analysis of "price runs" in daily financial indices: Dynamically assessing market geometric distributional behavior.

PLoS ONE, 2022
In financial time series there are time periods in which market indices values or assets prices increase or decrease monotonically. We call those events "price runs", "elementary uninterrupted trends" or just "uninterrupted trends".
Héctor Raúl Olivares-Sánchez, Carlos Manuel Rodríguez-Martínez, Héctor Francisco Coronel-Brizio, Enrico Scalas, Thomas Henry Seligman, Alejandro Raúl Hernández-Montoya   +5 more
doaj   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Geometry in Umayyad and Abbasid Art

Megaron, 2017
Ornaments and decorations were essential in the architectural design of the ninth century, the early Islamic period. Umayyad and Abbasid ornamentation, which was the basis of the decorative elements used by later Islamic states, developed from the 7th ...
Selim Kılıçoğlu, Nuran Kara Pilehvarian   +1 more
doaj   +1 more source

Direct computation of monodromy matrices and classification of 4d N $$ \mathcal{N} $$ = 2 heterotic-IIA dual vacua

Journal of High Energy Physics, 2022
We compute the monodromy matrices on the special geometry of 4d N $$ \mathcal{N} $$ = 2 Heterotic-IIA dual vacua in some simple cases by numerical evaluation of the period integrals, without assuming a geometric background.
Yuichi Enoki, Taizan Watari
doaj   +1 more source