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Computational Geometric and Algebraic Topology [PDF]

open access: yes, 2015
Computational topology is a young, emerging field of mathematics that seeks out practical algorithmic methods for solving complex and fundamental problems in geometry and topology.

core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Non-Abelian adiabatic geometric transformations in a cold strontium gas

open access: yesNature Communications, 2018
The symmetry group and geometric phase of a system are responsible for many quantum properties related to non-trivial topology. Here the authors show non-Abelian geometric phase in laser-coupled ultracold strontium atoms by using a tripod scheme.
F. Leroux   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Shortcut learning in geometric knot classification

open access: yesMachine Learning: Science and Technology
Classifying the topology of closed curves is a central problem in low dimensional topology with applications beyond mathematics spanning protein folding, polymer physics and even magnetohydrodynamics.
Djordje Mihajlovic, Davide Michieletto
doaj   +1 more source

Topology Unveiled: A New Horizon for Economic and Financial Modeling

open access: yesMathematics
Sinceits introduction in the 19th century to address geometric problems, topology as a methodology has undergone a series of evolutions, encompassing branches of geometric topology, point-set topology (analytic topology), algebraic topology, and ...
Yicheng Wei, Junzo Watada, Zijin Wang
doaj   +1 more source

A Data Model for Geometric, Semantic and Spatial Topology Validation of CityGML Datasets [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
3D city models are gaining importance across applications such as urban analytics and digital twins, where geometric and semantic data quality directly determine downstream usability.
L. Riegel, M. Betz, V. Coors
doaj   +1 more source

Algorithm for Topology Search Using Dilution of Precision Criterion in Ultra-Dense Network Positioning Service Area

open access: yesMathematics, 2023
User equipment (UE) location estimation in emerging 5G/B5G/6G Ultra-Dense Networks (UDNs) is a breakthrough technology in future wireless info-communication ecosystems.
Grigoriy Fokin, Andrey Koucheryavy
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

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