Results 91 to 100 of about 4,092,683 (376)

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis

Arthritis Care &Research, EarlyView.
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicine‐specific adverse events.
Lisa K. Stamp, Anne Horne, Borislav Mihov, Jill Drake, Janine Haslett, Peter Chapman, Daniel F. B. Wright, Christopher Frampton, Nicola Dalbeth   +8 more
wiley   +1 more source

The geometry of types

Proceedings of the 40th annual ACM SIGPLAN-SIGACT symposium on Principles of programming languages, 2013
We show that time complexity analysis of higher-order functional programs can be effectively reduced to an arguably simpler (although computationally equivalent) verification problem, namely checking first-order inequalities for validity. This is done by giving an efficient inference algorithm for linear dependent types which, given a PCF term ...
DAL LAGO, UGO, Barbara Petit
openaire   +3 more sources

Deformaciones isométricas infinitesimales de superficies multidimensionales ensambladas

Revista de Matemática: Teoría y Aplicaciones, 2012
The article introduces the concept of multidimensional pasted surfaces and considers the case of different dimensions in the surfaces to be pasted. Infinitesimal deformations of such surfaces are also considered.
Pavel Markov, Olman Trejos
doaj   +1 more source

An approach to BPS black hole microstate counting in an N = 2 STU model

Journal of High Energy Physics, 2020
We consider four-dimensional dyonic single-center BPS black holes in the N = 2 STU model of Sen and Vafa. By working in a region of moduli space where the real part of two of the three complex scalars S, T , U are taken to be large, we evaluate the ...
G.L. Cardoso, S. Nampuri, D. Polini
doaj   +1 more source

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

Web geometry [PDF]

Bulletin of the American Mathematical Society, 1982
This is a Chinese translation of the author's article in Bull. Am. Math. Soc., New. Ser. 6, No.1, 1-8 (1982; Zbl 0483.53013).
openaire   +4 more sources

Quaternionic CR Geometry

, 2013
Modelled on a real hypersurface in a quaternionic manifold, we introduce a quaternionic analogue of CR structure, called quaternionic CR structure.
Kamada, Hiroyuki, Nayatani, Shin
core   +1 more source

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

Arithmetic of decay walls through continued fractions: a new exact dyon counting solution in N $$ \mathcal{N} $$ = 4 CHL models

Journal of High Energy Physics, 2021
We use continued fractions to perform a systematic and explicit characterization of the decays of two-centred dyonic black holes in 4D N $$ \mathcal{N} $$ = 4 heterotic ℤ N CHL models.
Gabriel Lopes Cardoso, Suresh Nampuri, Martí Rosselló   +2 more
doaj   +1 more source