Results 1 to 10 of about 1,124 (56)

Bacteria Are New Targets for Inhibitors of Human Farnesyltransferase [PDF]

Frontiers in Microbiology, 2021
Farnesyltransferase inhibitors (FTIs) are focus for the treatment of several diseases, particularly in the field of cancer therapy. Their potential, however, goes even further, as a number of studies have evaluated FTIs for the treatment of infectious ...
Lea Weber, Anna Hagemann, Jila Kaltenhäuser, Manuela Besser, Patrick Rockenfeller, Anja Ehrhardt, Ewa Stuermer, Hagen Sjard Bachmann   +7 more
doaj   +2 more sources

Physiological Roles of Short-Chain and Long-Chain Menaquinones (Vitamin K2) in Lactococcus cremoris

Frontiers in Microbiology, 2022
Lactococcus cremoris and L. lactis are well known for their occurrence and applications in dairy fermentations, but their niche extends to a range of natural and food production environments. L. cremoris and L.
Yue Liu, Nikolaos Charamis, Sjef Boeren, Joost Blok, Alisha Geraldine Lewis, Eddy J. Smid, Tjakko Abee   +6 more
doaj   +1 more source

ModEnzA: Accurate Identification of Metabolic Enzymes Using Function Specific Profile HMMs with Optimised Discrimination Threshold and Modified Emission Probabilities

Advances in Bioinformatics, Volume 2011, Issue 1, 2011., 2011
Various enzyme identification protocols involving homology transfer by sequence‐sequence or profile‐sequence comparisons have been devised which utilise Swiss‐Prot sequences associated with EC numbers as the training set. A profile HMM constructed for a particular EC number might select sequences which perform a different enzymatic function due to the ...
Dhwani K. Desai, Soumyadeep Nandi, Prashant K. Srivastava, Andrew M. Lynn, Burkhard Morgenstern   +4 more
wiley   +1 more source

The Fox and the Rabbits—Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer′s Disease

International Scholarly Research Notices, Volume 2011, Issue 1, 2011., 2011
Classical population genetics shows that varying permutations of genes and risk factors permit or disallow the effects of causative agents, depending on circumstance. For example, genes and environment determine whether a fox kills black or white rabbits on snow or black ash covered islands.
C. J. Carter, A. Conti
wiley   +1 more source

Strain‐Specific Biotransformation of Grape Marc by Lactic Acid Bacteria: Genomic Validation and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Grape marc (GM) is a polyphenol‐rich winery byproduct that remains underutilized due to its complex fiber matrix, which limits the bioaccessibility of bound phenolics. While lactic acid fermentation (LAF) can enhance the release of these compounds, the strain‐specific metabolic fate of GM phenolics during digestion and colonic fermentation ...
Ziyao Liu, Hanjing Wu, Brendan Holland, Colin J. Barrow, Hafiz A. R. Suleria   +4 more
wiley   +1 more source

Study of Terpenoid Synthesis and Prenyltransferase in Roots of Rehmannia glutinosa Based on iTRAQ Quantitative Proteomics. [PDF]

Front Plant Sci, 2021
Chen P, Wei X, Qi Q, Jia W, Zhao M, Wang H, Zhou Y, Duan H.   +7 more
europepmc   +1 more source

Taxodione Inhibits Glioblastoma Proliferation and Potentiates the Cytotoxicity of Paclitaxel. [PDF]

ACS Chem Biol
Parella KJ, Solans MM, Vied C, Kononenko SN, Colegrove H, Zorio DAR, Basistyi VS, Frederich JH.   +7 more
europepmc   +1 more source

Farnesyl Diphosphate Synthase Promotes Proliferation of Hepatocellular Carcinoma Cells by Interacting With Glucose-6-Phosphate Dehydrogenase. [PDF]

Cancer Med
Liu J, Zhu Y, Lv J, Hu X, Zhong Y.
europepmc   +1 more source

GGPS1 Promoter Variant (rs3806394) Is Associated With Larger Simple Renal Cysts via Reduced GGPPS Expression. [PDF]

Hum Mutat
Wang K, Tang T, Xu T, Chen Z, Gou L, Wang Y, Wang D, Wu J, Wang X, Xue B, Xu X.   +10 more
europepmc   +1 more source

Estrogen-Dependent Regulation of FDPS in the Mouse Uterus and Its Expression in Endometrial Cancer. [PDF]

Int J Mol Sci
Suh Y, Kim B, Kim J, Lee J, Park S, Lee S, Lee MR, Lee HC, Choi Y.   +8 more
europepmc   +1 more source