Results 131 to 140 of about 10,218,222 (297)

Construction of a Theoretical Framework for Integrated Care of Elderly Palliative Care

Yixue yu zhexue
A scientific and systematic theoretical framework is the foundation for the effective implementation of geriatric palliative care. Grounded in integrated care theory and informed by the World Health Organization's integrated care for older people, the ...
Yunxia NI, Yan JIANG
doaj   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Geriatric Education and Training Program : implementing the GET program

, 2013
The Geriatric Education and Training (GET) Program provides a toolkit for educators to implement geriatric-focused training for acute care nurses, addressing the unique needs of older adults in hospitals.
Baumbusch, Jennifer, Shaw, Maureen, Leblanc, Marie-Eve, Kjorven, Mary Colleen, Geriatric Education and Training Program   +4 more
core   +1 more source

Integrating the Geriatric 5Ms: Enhancing Physical Therapy Care of Older Adults

The Geriatric 5Ms framework offers a comprehensive, person-centered approach to addressing the complex needs of older adults. Initially developed in geriatric medicine, the 4Ms strategy-Medications, Mind, Mobility, and what Matters Most to the patient ...
Quiben, Myla U, Larkin, Marni, Gras, Laura Z, Miller, Kenneth L, Lusardi, Michelle M, Hartley, Gregory W, Leach, Susan J   +6 more
core   +1 more source

ADISSP Drives Metabolic Reprogramming and Immune Suppression to Regulate Hepatocellular Carcinoma Progression and Immunotherapy Sensitivity

Advanced Science, EarlyView.
In HCC, ADISSP sustains IKKβ/NF‐κB signaling by inhibiting PPP1CA‐mediated IKKβ dephosphorylation, thereby inducing the expressions of SLC16A3 and CCL20. SLC16A3‐driven lactate remodeling promotes glycolysis, ferroptosis resistance, and M2 macrophage polarization, whereas CCL20 facilitates macrophage recruitment.
Tuan‐Song Zhang, Chen Xiong, Chen Yang, Yu‐Chuan Yan, Jie Li, Rui‐Zhe Li, Guo‐Qiang Pan, Jie Zou, Xiao‐Lu Zhang, Tao Li, Zhao‐Ru Dong   +10 more
wiley   +1 more source

CD34+ Progenitors Promote Ageing‐Associated Valve Sclerosis through the PDGFR–JNK–JUNB Pathway

Advanced Science, EarlyView.
In age‐related aortic valve sclerosis, non‐bone marrow CD34+ progenitor valvular interstitial cells (VICs) undergo transdifferentiation into periostin+ myofibroblast‐like VICs via the PDGFR‐JNK‐JUNB axis, driving leaflet thickening and fibrosis. Ablating non‐bone marrow CD34+ cells attenuates this remodeling.
Xiaoping Yang, Hong Wu, Guoqiang Ren, Yuesheng Zhang, Zuoshi Wen, Pengwei Zhu, Zhangquan Ying, Liujun Jiang, Tingting Tao, Bohuan Zhang, Linwen Zhu, Han Wang, Han Zhang, Qingbo Xu, Jun Cheng, Honghua Ye   +15 more
wiley   +1 more source

Core Competencies of the Modern Geriatric Cardiologist: A Framework for Comprehensive Cardiovascular Care in Older Adults

Background: The rapid ageing of the cardiovascular population has profoundly transformed clinical practice, with an increasing proportion of patients presenting advanced age, frailty, multimorbidity, and functional vulnerability.
Esteban, Marl\ue8ne, Nisse Durgeat, Sophie, Marc Harboun, Harboun, Marc, Marlène Esteban, Alejandro Mondragon, Esser, R\ue9mi, Marine Larbaneix, Olivier Maurou, Sophie Nisse Durgeat, Farges, Christine, Larbaneix, Marine, Rémi Esser, Maurou, Olivier, Christine Farges, Mondragon, Alejandro   +15 more
core   +1 more source

Cardiac Endothelial Enhancer RNA Tek‐e1 Restores Microvascular Homeostasis After Myocardial Infarction

Advanced Science, EarlyView.
Hypoxia‐induced KDM5A downregulation establishes a distinct endothelial repair programme, increasing H3K4me3 at the Tek promoter and intronic enhancer, enabling ISL1 to coordinately activate Tek transcription and induce enhancer‐RNA Tek‐e1. This cis‐regulatory RNA is essential for additional Tek/TIE2 induction through R‐loop formation and reinforced ...
Yang Lyu, Kun Yang, Yunzhi Ling, Jiahui Cheng, Jiaran Shi, Shiyu Hu, Changyi Zhou, Wei Wei, Hanchuan Chen, Xiang Wei, Zengru Wang, Zhi Xiong, Chenxi Yang, Su Zou, Rui Shen, Yuanyue Song, Gaofeng Zhang, Rifeng Gao, Kaiyang Lin, Yingjia Xu   +19 more
wiley   +1 more source

Nutrition in Geriatric Palliative Care [PDF]

, 2019
- 1 - Abstract Geriatric palliative care integrates two medical disciplines, namely geriatrics, focused on the diagnosis and treatment of diseases specific to the elderly, and palliative care, which is a comprehensive, active and qualified approach aimed
Vodičková, Věra
core  

The Importance of Geriatric Care Models

, 2018
I am delighted to edit this Special Issue of Geriatrics focusing on Geriatric Care Models.
James S. Powers, James S. Powers
core   +1 more source