Results 51 to 60 of about 5,273,924 (306)

Perspectives and experiences of patients and healthcare professionals with geriatric assessment in chronic kidney disease: a qualitative study

BMC Nephrology, 2021
Background Older patients with end-stage kidney disease (ESKD) often live with unidentified frailty and multimorbidity. Despite guideline recommendations, geriatric assessment is not part of standard clinical care, resulting in a missed opportunity to ...
Carlijn G. N. Voorend, Noeleen C. Berkhout-Byrne, Yvette Meuleman, Simon P. Mooijaart, Willem Jan W. Bos, Marjolijn van Buren   +5 more
doaj   +1 more source

Palliative Care Training for Geriatric Psychiatry Fellows: A National Survey Project

The American journal of geriatric psychiatry, 2021
Objectives: Palliative care is an essential part of the standard of care for individuals with serious medical illnesses. Integration of palliative care and mental health is important for elderly patients with medical and psychiatric comorbidities ...
Lauren Fields, D. Shalev, M. Nathanson, P. Shapiro   +3 more
semanticscholar   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Geriatric Care in Its Infancy in Punjab: A Narrative Review

Journal of the Indian Academy of Geriatrics
Geriatric care, which encompasses medical, psychological, social, and rehabilitative support, is essential to ensure the dignity, independence, and well-being of older adults.
Jasmine Kaur, Lal Dhruvendra, Akshay Kumar   +2 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

T cell-related diagnostic model and the underlying mechanism related to PRF1-mediated glycolysis in sepsis: evidences from single-cell, bulk transcriptomics, and experiment validation

European Journal of Medical Research
Aim Sepsis is a serious systemic inflammatory response. We aimed to construct a T cell-related diagnostic model for sepsis and uncover the underlying mechanisms. Methods Through downloading the single-cell RNA-sequencing (scRNA-seq) and RNA-seq data from
Fu Tian, Hui Chen, Zhicheng Huang, Kai Qiu   +3 more
doaj   +1 more source

Central nervous system insulin signaling can influence the rate of insulin influx into brain

Fluids and Barriers of the CNS, 2023
Background Insulin transport across the blood-brain barrier (BBB) is a highly regulated, saturable process, known to be affected by many peripheral substrates including insulin itself and triglycerides.
Van Nguyen, Peter Thomas, Sarah Pemberton, Alice Babin, Cassidy Noonan, Riley Weaver, William A. Banks, Elizabeth M. Rhea   +7 more
doaj   +1 more source

Models of Care in Geriatric Intensive Care—A Scoping Review on the Optimal Structure of Care for Critically Ill Older Adults Admitted in an ICU

Critical Care Explorations, 2022
OBJECTIVE:. A growing proportion of critically ill patients admitted in ICUs are older adults. The need for improving care provided to older adults in critical care settings to optimize functional status and quality of life for survivors is acknowledged,
Tasheen Wissanji, MD, MSc, Marie-France Forget, MD, MSc, John Muscedere, MD, Dominique Beaudin, MD, Richard Coveney, MBSI, Han Ting Wang, MD, MSc   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source