Results 241 to 250 of about 146,183 (351)
Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians
Aging Cell, EarlyView.Targeted‐proteome analysis suggests that a single acute exercise session may attenuate inflammation at the end of the human lifespan. ABSTRACT
Centenarians exhibit remarkable disease resilience despite chronic low‐grade inflammation. We investigated the inflammation‐related proteome response to acute exercise in seven centenarians (100–104 years ...Abel Plaza‐Florido, Lidia B. Alejo, Inmaculada Pérez‐Prieto, Pedro Carrera‐Bastos, María Rosado Muñoz, Itziar Pagola Aldazabal, David Barranco‐Gil, Alejandro Santos‐Lozano, Gabriel Rodríguez‐Romo, Natalia Yanguas‐Casás, Shlomit Radom‐Aizik, Alejandro Lucia, Carmen Fiuza‐Luces +12 morewiley +1 more sourceCognitive and behavioural predictors of survival in Alzheimer disease:results from a sample of treated patients in a tertiary-referral memory clinic [PDF]
, 2012 Agüero-Torres, Andersen, Brandt, Brookmeyer, Buchner, Cox, Cummings, Doody, Ferri, Folstein, Gambassi, General Register Office for Scotland, Helmer, Hicks, Hötte, Inouye, ISD Scotland, Kaplan, Knopman, Landi, Larson, Lawton, Lezak, Luchsinger, Martyn, McGurn, McKhann, Mental Welfare Commission for Scotland, Mielke, Miller, Morgan, Musicco, Nelson, Newcomer, Rait, Reisberg, Richards, Robbins, Scarmeas, Scarmeas, Schneider, Sinforiani, Solfrizzi, SPSS Inc, Starr, Starr, Starr, Starr, Stern, Stern, Stern, Stern, Thomas, Tsai, Tun, Van Dijk, Wang, Whalley, Whitmer, Wolfson +59 morecore +1 more sourceIdentification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age
Aging Cell, EarlyView.Human skin fibroblasts in vitro preserve the memory of age and health. ABSTRACT
Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite ...Chloé Brodeau, Camille Joly, Anaïs Chekroun, Jean Nakhle, Vincent Blase, Nicolas Espagnolle, Cédric Dray, Armelle Yart, Valérie Planat, Margot Tertrais, Julien Fassy, Sophie Guyonnet, Wan‐Hsuan Lu, Philipe de Souto Barreto, Olivier Teste, Marie Tremblay‐Franco, Kamaryn T. Tanner, Alan A. Cohen, Audrey Carriere, Louis Casteilla, Isabelle Ader, IHU HealthAge/Open Science group +21 morewiley +1 more sourceA Metabolite Score of Unintentional Weight Loss Explained a Substantial Proportion of Associated Mortality and Mobility Limitation Risk in a Biracial Older Cohort
Aging Cell, EarlyView.A metabolite‐based score for short‐term unintentional weight loss was independently associated with mortality and mobility limitation risks in healthy older adults. It accounted for over 20% of the excess risk linked to unintentional weight loss, independent of lifestyle and medical history, suggesting a shared metabolic mechanism that remains ...Shanshan Yao, Megan M. Marron, Samaneh Farsijani, Iva Miljkovic, George C. Tseng, Ravi V. Shah, Venkatesh L. Murthy, Anne B. Newman +7 morewiley +1 more sourceAssociations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20–93: The INSPIRE‐T Project
Aging Cell, EarlyView.This study assessed skin biomechanics using the Cutometer in 441 community‐dwelling adults aged 20–93 from the INSPIRE‐T cohort. We demonstrated that skin elasticity and viscoelasticity parameters were associated with the intrinsic capacity (IC) score, a functional marker of healthy aging encompassing cognition, locomotion, psychology, vitality, and ...Wan‐Hsuan Lu, Sophie Guyonnet, Jérémy Raffin, Sandrine Bessou‐Touya, Katia Ravard Helffer, Pascale Bianchi, Jimmy Le Digabel, Paul Bensadoun, Jean‐Marc Lemaitre, Philipe de Souto Barreto, Bruno Vellas, the IHU HealthAge INSPIRE/Open Science study group, Sophie Guyonnet, Bruno Vellas, Lauréane Brigitte, Agathe Milhet, Elodie Paez, Emeline Muller, Sabine Le Floch, Catherine Takeda, Catherine Faisant, Françoise Lala, Gabor Abellan Van Kan, Zara Steinmeyer, Antoine Piau, Tony Macaron, Davide Angioni, Pierre‐Jean Ousset, Mélanie Comté, Nathalie Daniaud, Fanny Boissou‐Parachaud, Sandrine Andrieu, Christelle Cantet, Yves Rolland, Philipe de Souto Barreto, Fabien Pillard, Bernard Teysseyre, Marie Faruch, Pierre Payoux, Catherine Takeda, Neda Tavassoli, Marie Dorard, Bénédicte Razat, Camille Champigny, Sophie Guyonnet, Cédric Dray, Jean‐Philippe Pradère, Angelo Parini, Yohan Santin, Dominique Langin, Pierre Gourdy, Laurent O. Martinez, Anne Bouloumié, Angelo Parini, Nicolas Fazilleau, Roland Liblau, Jean‐Charles Guéry, Michel Simon, Nicolas Gaudenzio, Luciana Bostan, Hicham El Costa, Nabila Jabrane Ferrat, Philippe Valet, Cedric Dray, Isabelle Ader, Valérie Planat, Louis Casteilla, Pierre Payoux, Patrice Peran, Cyrille Delpierre, Sandrine Andrieu, Claire Rampon, Noelie Davezac, Bruno Guiard, Nathalie Vergnolle, Jean‐Paul Motta, Sara Djebali, Pauline Floch, Céline Deraison, Chrystelle Bonnart, Jean‐Emmanuel Sarry, Nicola Coley, Sophie Guyonnet, Christelle Cantet, Jessica Pontary, Sandrine Andrieu +85 morewiley +1 more sourceStrategic intelligence monitor on personal health systems phase 3 (SIMPHS3). Integrated care programme for older in- and out-patients University Hospital of Getafe (Spain)., case study report [PDF]
, 2015 Abadie, Fabienne, Institute for Prospective Technological Studies (Joint Research Center), Mansoa, Francesco, Peinado, Ignacio, Rodríguez Mañas, Leocadio, Sánchez, Alberto, Villalba, Elena +6 morecore +1 more source