Results 51 to 60 of about 190,507 (315)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Correlation of RUNX2 Variants With Craniofacial–Dental Phenotypes in Cleidocranial Dysplasia

Clinical and Experimental Dental Research
Objectives Cleidocranial dysplasia (CCD) is a rare RUNX2‐related skeletal disorder characterized by craniofacial anomalies and skeletal Class III malocclusion.
Pintu‐on Chantarawaratit, Sermporn Thaweesapphithak, Pisha Pittayapat, Thantrira Porntaveetus   +3 more
doaj   +1 more source

Digital fabrication of customized intraoral appliances for head and neck radiotherapy

Heliyon, 2023
Introduction: The radiotherapy received by head and neck cancer patients commonly has adverse effects on oral tissue and the muscles of mastication. This short communication describes the digital fabrication of intraoral appliances for radiotherapy and ...
Anussara Prayongrat, Sarin Kitpanit, Chawalit Lertbutsayanukul, Pipop Saikaew, Thirayu Boonrueng, Trakol Mekayarajjananonth, Anjalee Vacharaksa   +6 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Three Years Survival of Elderly Cancer Patients in Indonesia: Do We Need a Different Approach?

Acta Medica Indonesiana, 2020
Background: the number of elderly people in Indonesia is increasing. Additionally, cancer prevalence among older patients is also increasing. However, studies assessing clinical factors associated with the survival of elderly patients with cancer are ...
Noorwati Sutandyo, Sri Agustini Kurniawati, Nia Novianti Siregar, Nina Kemala Sari   +3 more
doaj   +2 more sources

Radiographic evaluation of orodental anomalies in a Thai population: prevalence, supernumerary teeth characteristics, and associated factors

BMC Oral Health
Background Orodental anomalies encompass a range of dental conditions affecting tooth number, morphology, and eruption patterns. Among these, supernumerary teeth (hyperdontia) are of particular clinical significance due to their potential to disrupt ...
Anmol Fayez Anny, Kausar Sadia Fakhruddin, Rocharles Fontenele, Thantrira Porntaveetus   +3 more
doaj   +1 more source

Biomimicry and rehabilitation of dental tissues in geriatric population - An overview

Journal of Oral Research and Review
As the elderly population continues to grow worldwide, dental care tailored to older adults has become increasingly important. This article examines the various clinical and systemic factors that contribute to oral health challenges in geriatric patients,
Ekta Choudhary, Vanshika Nagar
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Management of Gynecological Cancer Patients Older than 70 Years of Age

International Journal of Gerontology, 2015
Background: The incidence of geriatric oncology patients has not been studied very well. A retrospective study of the incidence of geriatric patients with malignant gynecological disease is therefore presented. Patients and methods: From 1982 until 2006,
Galina Chakalova
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source