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The function of Toll-like receptor 2 in control of transcriptome responses to the microbiome and microbiome composition. [PDF]
Liu L, Spaink HP.
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Population size interacts with reproductive longevity to shape the germline mutation rate. [PDF]
Zhu L, Beichman A, Harris K.
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The use of PARP inhibitors as maintenance therapy in ovarian carcinosarcoma: A case series. [PDF]
Dinicu AI, Rose PG.
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Myeloid neoplasms with germ line RUNX1 mutation
International Journal of Hematology, 2017Familial platelet disorder with propensity to myeloid malignancies (FPD/AML) is an autosomal dominant disorder characterized by quantitative and/or qualitative platelet defects with a tendency to develop a variety of hematological malignancies. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML. Notably, about
Yoshihiro, Hayashi +3 more
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Familial Gastrointestinal Stromal Tumors and Germ-Line Mutations
New England Journal of Medicine, 2007To the Editor: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the conte...
MCWHINNEY SR +2 more
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Germ-Line Mutations, Pancreatic Inflammation, and Pancreatic Cancer
Clinical Gastroenterology and Hepatology, 2009The fundamental problem underlying pancreatic cancer is altered genetics. Rare germ-line mutations lead to familial cancer syndromes that may include pancreatic cancer. But why do some people develop pancreatic cancer while others develop cancer in other organs, or not at all?
David, Whitcomb, Julia, Greer
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Germ line mutations associated with breast cancer susceptibility
European Journal of Cancer, 2001Laboratory-based research in germ line mutations associated with breast cancer susceptibility is rapidly being integrated into clinical practice with profound implications. A Medline search was performed for all relevant articles published since 1990. Where appropriate, historical articles referenced in those identified were also reviewed.
P T, Iau, R D, Macmillan, R W, Blamey
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Germ-line and somatic PTPN11 mutations in human disease
European Journal of Medical Genetics, 2005Reversible protein tyrosyl phosphorylation of cell surface receptors and downstream intracellular transducers is a major regulatory mechanism used to modulate cellular responses to extracellular stimuli, and its deregulation frequently drives aberrant cell proliferation, survival and/or differentiation.
Marco, Tartaglia, Bruce D, Gelb
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