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To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm [PDF]
International Journal of Molecular Sciences, 2021 In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neoplasias originating from fetal or neonatal germ cells, maintain such dichotomy
Massimo De Felici +5 more
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Germ cell tumors in children. [PDF]
Virchows ArchPediatric germ cell tumors represent a rare but biologically diverse group of neoplasms arising from pluripotent primordial germ cells. The 2022 edition of the WHO Classification of Pediatric Tumors introduced the first organ independent classification of germ cell tumors, reflecting advances in molecular biology, histopathology, and clinical practice.
Bode PK +3 more
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Dysgerminomas: germ cell tumors exhibit high expression of PD-L1 and associated with high TILs and good prognosis [PDF]
Scientific ReportsOvarian germ cell tumors (OVGCTs) account for 28% of all diagnosed ovarian cancers, and malignant germ cell tumors specifically account for approximately 13% of diagnosed ovarian cancers in Saudi Arabia. Although most germ cell tumor patients have a high
Kholoud Alwosaibai +9 more
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Spermatocytic tumor – case report [PDF]
Liječnički vjesnik, 2021 According to the newest WHO classification tumors of the testis are divided into germ cell tumors derived from germ cell neoplasia in situ, germ cell tumors unrelated to germ cell neoplasia in situ, sex cord-stromal tumors, tumors containing both germ ...
Tonći Vodopić +5 more
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Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report
Acta Clinica Croatica, 2023 Intracranial germ cell tumors are rare brain tumors that are distinguished based on their histology and selected tumor markers. Non-germinomatous germ cell tumors are a diverse group of such tumors having the poorest prognosis.
Nikolina Sesar +3 more
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Extragonadal Germ Cell Tumors in Children and Adolescents - a 20 Year Study [PDF]
Modern Medicine, 2020 Germ cell tumors (GCTs) are rare neoplasms which are seen in all age groups and both sexes. GCTs in the pediatric age group show considerable variation from their adult counterparts in relation to site, histological type, clinical and radiological ...
Felice FAIZAL +2 more
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Neuro-Oncology, 2012 Central nervous system (CNS) germ cell tumors (GCTs) are separated into germinomas and nongerminomatous germ cell tumors (NGGCTs). The latter group includes teratoma (mature and immature), teratoma with malignant transformation, yolk sac tumor, embryonal carcinoma, choriocarcinoma, and mixed GCTs.
Q.-y. Yang +184 more
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Primary Mediastinal Choriocarcinoma in a Female Patient with Vaginal Bleeding: A Case Report [PDF]
Middle East Journal of Cancer, 2022 Primary mediastinal germ cell tumors accounts for about 3%-15% of the mediastinal malignancies. Nonseminomatous tumors make a small percentage of germ cell tumors.
Nasrin Namdari +2 more
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Treatment of Germ Cell Testicular Cancer
Acta Clinica Croatica, 2020 Germ-cell testicular cancer (GCTC) is a malignant neoplasm derived from the primordial germ cell. Although it accounts for approximately 1% of all malignancies in men, it is the most common cancer of younger male population, with the highest incidence ...
Ana Koši Kunac +3 more
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