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Germ-Cell Tumors

2015
Cancer originating from germ cells is a special disease, characterized by increased incidence in young men (18–40 years) and extremely good prognosis, even if it is diagnosed in advanced stages. The vast majority of these cancers are originated in the gonads (testicles), while a small percentage of germ cell tumors may appear in midline extragonadal ...
S. Suster
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Germ Cell Tumors

2013
In adults, 30 % of ovarian tumors are of germ cell origin [1]; the great majority of germ cell tumors (95 %) are benign and consist of mature cystic teratomas (MCT), usually designated dermoid cysts [2]. In children and adolescents, more than 60 % of ovarian neoplasms are of germ cell origin, and one-third of them are malignant [2–6].
Jean Noel Buy, Michel Ghossain
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Germ Cell Tumors [PDF]

open access: possibleSurgical Clinics of North America, 2006
The category of germ cell tumors includes a broad array of histologic subtypes ranging from the benign, mature teratoma to the primitive, aggressive embryonal carcinoma (Box 1). These tumors share their origin in a primordial germ cell with multipotent capacity for differentiation along a variety of pathways.
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Germ-Cell Tumors

New England Journal of Medicine, 2007
Testicular cancer is rare, accounting for 1% to 2% of all male malignancies. Nearly 90% to 95% of tumors arising in testis are germ cell in origin. Other sites of malignant germ cell tumors include the retroperitoneum, mediastinum, sacrococcygeal region, and pineal gland. The highest incidence is seen in Scandinavian countries, particularly Denmark (1).
De Giorgi U, Pedrazzoli P, Rosti G
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Germ Cell Tumors

2019
Germ cell tumors affecting the nervous system include germinoma, yolk sac tumor, embryonal carcinoma, choriocarcinoma, teratoma, and mixed germ cell tumors.
Maurizio Colecchia, Alessia Bertolotti
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Germ Cell Tumors

Hematology/Oncology Clinics of North America, 1992
The development of modern surgical staging and effective chemotherapy regimens has markedly improved outcome of treatment of ovarian germ cell tumors. Almost all patients with completely resected tumors will survive their disease. Those with tumors other than dysgerminoma should all receive adjuvant chemotherapy. Patients with stage IA dysgerminoma can
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