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Biology of Germ Cell Tumors

Hematology/Oncology Clinics of North America, 2011
Testicular cancer has been a model for a curable malignancy. The existence of an array of potential new therapies is the result of a prodigious effort in the researching and defining of the molecular components of the cancer phenotype and the subsequent rational design of agents to target candidate pathways.
Syed A. Hussain   +3 more
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Chemotherapy for Germ Cell Tumors

Urologic Clinics of North America, 1987
With the advent of cisplatin-based chemotherapy and the incorporation of adjunctive surgery, 70 to 80 per cent of patients with advanced germ cell tumors are cured. Serum tumor markers are important diagnostically and prognostically and are necessary for monitoring response to therapy.
George J. Bosl, Robert J. Motzer
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Germ-Cell Tumors of the Mediastinum

Advances in Anatomic Pathology, 1998
Germ-cell tumors occurring primarily in the mediastinum have been well recognized in the literature for many years. Unfortunately, most of what has been written on these tumors has been in the form of case reports and small series of cases, thus precluding a better understanding of their clinical and demographic features, as well as of their biologic ...
Cesar A. Moran, Saul Suster
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Surgery for germ cell tumors

Seminars in Surgical Oncology, 2000
We performed a review of the current modalities of surgical treatment of malignant ovarian germ cell tumors by clinical stages and histological types. Stage IA dysgerminoma is performed with a unilateral salpingo-oophorectomy (USO) without chemotherapy. However, for Stage IB or IC patients with dysgerminoma, USO plus chemotherapy as a primary treatment
Ryuichi Kudo, Satoru Sagae
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Germ cell tumors of the ovary

Cancer Treatment Reviews, 2008
Malignant ovarian germ cell tumors (MOGCTS) are rare but curable at all stages of disease. This review gives an outline of the management of this disease.We performed a literature search in the PubMed of almost all relevant articles concerning MOGCTs on pathology, prognostic factors, surgery, post-operative therapy and late effects of therapy.
Pectasides, D.   +2 more
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Germ Cell Tumors

2009
Germ cell tumors of the CNS are typically midline lesions, commonly affecting the pineal and suprasellar regions, and are similar to their counterparts arising in the gonads. Types, histological and immunohistochemical features of CNS germ cell tumors are essentially the same as gonadal or extra-gonadal extracranial germ cell tumors.
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Pediatric germ cell tumor

Current Problems in Cancer, 1999
Malignant germ cell tumors are relatively uncommon, accounting for approximately 3% of all childhood malignancies. Occurring with an incidence of approximately 4 per million among children less than 15 years of age, they account for approximately 225 new cases per year in the United States. Germ cell tumors occur in both gonadal and extragonadal sites,
Philip P. Breitfeld   +1 more
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Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide.

New England Journal of Medicine, 1987
Standard chemotherapy for disseminated germ-cell tumors includes a combination of cisplatin, vinblastine, and bleomycin, but this regimen produces substantial neuromuscular toxicity.
S. Williams   +5 more
semanticscholar   +1 more source

Germ Cell Tumors

1986
The WHO classification has followed the trend of the English-speaking countries in defining the two-cell-type pattern pineal tumors as germinomas.
Klaus-Joachim Zülch   +1 more
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Extragonadal Germ-Cell Tumors

Annals of Internal Medicine, 1982
Excerpt To the editor: The article by Hainsworth and associates (1) was an outstanding example of continued progress in medical oncology.
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