Results 151 to 160 of about 3,915,663 (339)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Geological modelling of the Triassic Stuttgart Formation at the Ketzin CO2 storage site, Germany

, 2013
Ben Norden, Peter Frykman
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The role of risk communication in public health interventions. An analysis of risk communication for a community quarantine in Germany to curb the SARS-CoV-2 pandemic

, 2021
Juliane Scholz, Wibke Wetzker, Annika Licht, Rainer Heintzmann, André Scherag, Sebastian Weis, Mathias W. Pletz, Cornelia Betsch, Michael Bauer, Petra Dickmann   +9 more
openalex   +1 more source

Initial conditions and regional performance in the aftermath of disruptive shocks: the case of East Germany after socialism [PDF]

, 2022
Michael Fritsch, Michael Wyrwich
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

How land-use intensity affects sexual and parthenogenetic oribatid mites in temperate forests and grasslands in Germany [PDF]

, 2021
Katja Wehner, Romina Schuster, Nadja K. Simons, Roy A. Norton, Nico Blüthgen, Michael Heethoff   +5 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

The Effect of a New Antiandrogenic Steroid, 6-Chloro-17-hydroxy-1α,2α-methylenepregna-4,6-diene-3,20-dione Acetate (Cyproterone Acetate)**This substance was synthesized by Dr. Wiechert, Schering AG, Berlin, Germany.on the Sebaceous Glands of Mice††TFrom the Main Laboratory of Schering A.G, Berlin, Germany.

, 1966
F. Neumann, W. Elger
openalex   +1 more source

Influence of cloud processing on CCN activation behaviour in the Thuringian Forest, Germany during HCCT-2010 [PDF]

, 2014
Silvia Henning, K. Dieckmann, K. Ignatius, Michael Schäfer, Philipp Zedler, Eliza Harris, Baerbel Sinha, Dominik van Pinxteren, Stephan Mertes, W. Birmili, Maik Merkel, Zhijun Wu, Alfred Wiedensohler, Heike Wex, Hartmut Herrmann, Frank Stratmann   +15 more
openalex   +1 more source