Results 191 to 200 of about 3,966,612 (344)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

On Gender-Specific FIT Cutoffs in the Swedish Colorectal Cancer Screening Program. [PDF]

United European Gastroenterol J
Brenner H, Ola I, Seum T.
europepmc   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

"Remember, we don't have race categories here": contradictions and reflections on racism, environment, and health from an interview study among Black German researchers, educators, and care providers. [PDF]

Front Public Health
Payne-Sturges DC.
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Evaluation of Risk Score for Isolated Surgical Aortic Valve Replacement and Transcatheter Aortic Valve Replacement-Results from the German National Quality Database. [PDF]

Interdiscip Cardiovasc Thorac Surg
Böning A, Beckmann A, Heinemann M, Doenst T, Taghiyev ZT, Niemann B.   +5 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Most German Speakers Ignore the Cue That Best Predicts Plural Class. [PDF]

Open Mind (Camb)
McCurdy K, O'Donnell TJ, Lopez A, Goldwater S.   +3 more
europepmc   +1 more source

Germanic Etymologies. [PDF]

Modern Language Notes, 1898
openaire   +1 more source

O050: Antibiotics in 70 German intensive care units: risk factors for high overall consumption [PDF]

, 2013
Sandra M. Schneider, Frank Schwab, Petra Gastmeier, Elisabeth Meyer   +3 more
openalex   +1 more source