Results 241 to 250 of about 3,915,663 (339)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Today, Tomorrow, and Overmorrow: The Acquisition of Deictic Temporal Terms in English and German. [PDF]

Open Mind (Camb)
Steele K, Bánki A, Markova G, Hoehl S, Tillman KA.   +4 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Basic Science and Pathogenesis. [PDF]

Alzheimers Dement
Delvenne A, Rizzo M, Zhang B, Levit M, Zetterberg H, Blennow K, Kollmorgen G, Krüger R, Fernandes SBG, Aarsland D, Borejko O, Chokoshvili D, van der Flier WM, Lemstra AW, Tijms BM, Petzold GC, Spottke A, Frisoni GB, Brockmann K, Gasser T, Fladby T, Wettergreen M, Jessen F, Düzel E, Höglinger GU, Chevalier C, Krishnan R, Teunissen CE, Vos SJB, Visser PJ, IMI EPND consortium.   +30 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Envisioning grassroots science: DIY biology in Canada, Britain, and Germany. [PDF]

PLoS One
Eireiner AV.
europepmc   +1 more source

Multidirectional mistrust: German female volunteers’ emotion work in the context of male deportation and return from Europe to Senegal

Karlien Strijbosch
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Epidemiology and treatment of malignant ovarian germ cell and sex cord stromal tumors in germany: a population-based cancer registry study from 2016 - 2021. [PDF]

Sci Rep
Jung D, Branscheidt S, Wittenberg I, Schmidt-Pokrzywniak A, Piontek D, Brand T, Klora M, Zeissig SR, Beck N, Feller A, Hermann S, Kanbach J, Luttmann S, Pritzkuleit R, Braun B, Erb C, Kusche H, Robers G, Weitmann K, Abnaof K, Kim-Wanner SZ, Reil D, von Rüsten A, Oesterling F, Stang A, Ronckers C, Bremensdorfer C, Justenhoven C, Hasenburg A.   +28 more
europepmc   +1 more source

Media Coverage of Climate Activist Groups in Germany

Fabian Dablander, Simon Wimmer, Jonas M B Haslbeck   +2 more
openalex   +2 more sources